Multi-Layer Blood Filtration for On-Site Component Separation
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Solution Overview
Problem
Existing methods for separating individual blood components require complex procedures and specialized equipment, limiting their applicability to well-equipped laboratories.
Innovation Solution
A multi-layered filter system with filter units of varying pore sizes and materials is used to separate blood components, allowing for on-site extraction and diagnosis without specialized equipment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional methods are used to separate blood components, then separation precision is improved, but device complexity increases
Solution Approach 1:
The patent combines multiple filter units with different pore sizes into a single integrated multi-layered filter device. This merging of filtration functions into one device allows for precise separation of blood components (cells, platelets, exosomes, proteins) without requiring multiple separate instruments and complex procedures, thus reducing device complexity while maintaining separation precision
Solution Approach 2:
The multi-layered filter is segmented into multiple filter units with progressively smaller pore sizes arranged in sequence. Each filter unit is designed to capture specific size ranges of blood components, enabling precise separation through a single device without requiring complex multi-step procedures
2Measurement precision
If specialized equipment and reagents are used for blood component separation, then separation precision is improved, but ease of operation deteriorates
Solution Approach 1:
The multi-layered filter device performs blood component separation autonomously through passive filtration based on size differences. The device requires no external power source, complex controls, or specialized reagents - blood simply passes through the filter units and components are automatically separated by size, making it easy to operate in field settings without specialized equipment
Solution Approach 2:
The device utilizes porous filter materials with controlled pore sizes to achieve separation. The filter units are made of porous materials that allow selective passage of blood components based on their size, eliminating the need for complex mechanical systems, reagents, or specialized equipment while maintaining separation precision
3Adaptability or versatility
If multiple filter units with different pore sizes are used, then adaptability is improved, but device complexity increases
Solution Approach 1:
Multiple filter units with different pore sizes are merged into a single multi-layered filter device with a compact structure. This integration allows the device to adapt to various blood component separation needs (cells, platelets, exosomes, proteins) while maintaining a relatively simple overall structure that can be disassembled for collection and analysis
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-layered filter simplifies the separation process, enabling blood component analysis in non-laboratory settings and facilitating the use of individual components for diagnosis.
Implementation Method 1
a first filter unit for separating blood cells from a whole blood sample, a second filter unit for separating cell fragments having blood platelet and exosome, and a third filter unit for separating proteins, wherein the whole blood sample is separated into blood components through each filter unit provided to have various pore sizes
Data Source
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AI summary
This disclosure relates to a multi-layered filter for separating blood components and a disease diagnosis kit using the same. The multi-layered filter for separating blood components according to the present disclosure may include a first filter unit configured to separate blood cells from a whole blood sample, a second filter unit configured to separate cell fragments having blood platelet or exosome, and a third filter unit configured to separate protein, wherein the whole blood sample is separated into blood components by passing through the filter units provided to have different pore sizes, thereby effectively separating individual components of the blood without a separate machine. In addition, after filtering, the multi-layered filter may be disassembled to diagnose each component remaining in the filter so as to be utilized for diagnosis.