Multi-Lumen Biosensor with Nitric Oxide Donor
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Solution Overview
Problem
Conventional medical devices with integrated biosensors are susceptible to coagulation and biofilm formation, which limits their effectiveness and useful duration for analyte monitoring.
Innovation Solution
A medical device with a multi-lumen design, where one lumen contains a nitric oxide donor material that releases NO gas upon contact with moisture, communicating it to the biosensor lumen to prevent bacterial proliferation and coagulation, thereby enhancing the device's anti-bacterial and anti-coagulation effects and improving sensing accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If conventional medical devices with integrated biosensors are used, then analyte monitoring capability is provided, but coagulation and biofilm formation occur at the sensor componentry limiting useful duration
Solution Approach 1:
The device incorporates a nitric oxide donor in a first lumen that proactively releases nitric oxide gas to create a protective environment around the biosensor before coagulation and biofilm formation can occur. This preliminary anti-action prevents the harmful factors from compromising the sensor surface, thereby extending the useful duration of the biosensor.
2Measurement precision
If conventional medical devices with integrated biosensors are used, then analyte monitoring is enabled, but sensing quality deteriorates due to coagulation and biofilm formation
Solution Approach 1:
The nitric oxide donor proactively releases nitric oxide gas that migrates to the biosensor surface to prevent coagulation and biofilm formation, thereby maintaining sensing quality throughout the device's operational life. This preliminary protective action ensures that the sensor surface remains clean and functional for accurate analyte monitoring.
3Measurement precision
If point-of-care devices are used for analyte analysis, then accurate concentration measurements are obtained, but sample throughput is limited and frequent draws are required
Solution Approach 1:
The medical device enables continuous in-situ analyte monitoring by the patient's body fluids flowing past the biosensor, eliminating the need for repeated manual blood draws and external point-of-care device analysis. This self-service approach provides continuous high-throughput monitoring while maintaining accurate concentration measurements.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The NO gas extends the duration of use and improves sensing quality by reducing interferences, leading to more reliable and frequent analyte measurements.
Implementation Method 1
utilize nitric oxide (NO) donor materials to release NO gas upon contact with moisture
Implementation Method 2
mitigate bacterial proliferation, coagulation, or a combination thereof
Implementation Method 3
mitigate bacterial proliferation, coagulation, or a combination thereof
Implementation Method 4
A channel between the first and second lumens serves to communicate NO gas from the first lumen to a sensor-volume of the biosensor
Data Source
AI summary
The disclosure concerns medical devices configured to utilize nitric oxide (NO) donor materials to release NO gas upon contact with moisture in order to mitigate bacterial proliferation, coagulation, or a combination thereof, at a site of a biosensor integrated within the medical device. A novel multi-lumen medical device is described, the device having a first lumen for containing the NO donor material and producing the NO gas, and having a second lumen for housing biosensor componentry. A channel between the first and second lumens serves to communicate NO gas from the first lumen to a sensor-volume of the biosensor.