Multi-Lumen Tamper Tube for Local Thrombin Delivery
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Solution Overview
Problem
Existing closure devices for percutaneous punctures, particularly in large vessels like the femoral artery, face challenges in efficiently sealing the puncture site while minimizing blood loss and providing precise delivery of therapeutic agents.
Innovation Solution
A multi-lumen tamper tube is used to deploy a vascular closure device that includes a plug, suture, and locking member, with lumens to facilitate the delivery of pharmaceutical agents like thrombin directly to the puncture site, enhancing sealing and hemostasis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a single-lumen tamper is used for closure device deployment, then the device structure is simple, but it cannot efficiently deliver therapeutic agents to the puncture site
Solution Approach 1:
The tamper is divided into multiple lumens (first lumen for guidewire passage, second lumen for drug delivery, third lumen for additional functionality) within a single device structure. This segmentation allows simultaneous deployment of closure components and delivery of therapeutic agents through dedicated pathways, resolving the contradiction between maintaining structural simplicity and enabling multi-functionality.
Solution Approach 2:
The multi-lumen tamper serves multiple functions: deploying the closure device components (plug, locking member), delivering therapeutic agents (thrombin) to the puncture site, and providing structural support during the procedure. This multi-functionality within a single device resolves the contradiction by integrating what would otherwise require separate devices.
2Reliability
If pressure is applied manually to the puncture site after device removal, then no additional equipment is needed, but blood loss control is insufficient for large vessel punctures
Solution Approach 1:
The closure device with multi-lumen tamper is deployed through the puncture site before complete device removal, establishing the seal and drug delivery pathway in advance. The plug is positioned and secured within the puncture tract, and therapeutic agents can be delivered immediately, providing reliable hemostasis control before manual compression is applied.
Solution Approach 2:
The multi-lumen tamper acts as an intermediary device that facilitates both mechanical closure (through plug deployment) and pharmacological intervention (through drug delivery lumens). This intermediary structure enables controlled delivery of thrombin directly to the puncture site, enhancing hemostasis effectiveness beyond what manual pressure alone can achieve.
3Reliability
If thrombin is delivered systemically, then it can reach the puncture site, but blood loss increases due to systemic anticoagulation effects
Solution Approach 1:
The multi-lumen tamper enables localized delivery of thrombin directly to the puncture site through dedicated lumens. This local application accelerates clotting precisely where needed without exposing the entire circulatory system to anticoagulant effects, thereby resolving the contradiction between achieving reliable clotting and minimizing blood loss from systemic effects.
Solution Approach 2:
The closure device system with multi-lumen tamper provides self-contained drug delivery capability, allowing the puncture site to receive thrombin locally without requiring systemic administration. The device serves its own hemostasis needs through integrated drug delivery, eliminating the need for systemic thrombin injection and its associated blood loss risks.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-lumen tamper tube effectively seals large punctures by delivering thrombin to accelerate clotting, reducing blood loss and improving hemostasis, while ensuring structural integrity and controlled drug delivery.
Implementation Method 1
delivering thrombin to accelerate clotting, reducing blood loss and improving hemostasis
Data Source
AI summary
The present technology relates generally to devices and methods for closing percutaneous punctures, and more particularly to a multi-lumen tamper for such a device. A vascular closure device for sealing a percutaneous puncture in a wall of a body passageway is disclosed, the vascular closure device including a plug configured to engage a surface of the puncture; a suture configured coupled to the plug; a locking member configured to engage the plug; and a tamper comprising a first lumen and a second lumen.