Multi-Needle Bone Treatment Device for Osteonecrosis
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Solution Overview
Problem
Current treatments for osteonecrosis, such as Legg-Calve-Perthes disease, face challenges in effectively promoting bone regeneration and removing necrotic tissue, leading to inadequate healing and potential complications like bone resorption and external bone growth.
Innovation Solution
A method involving drilling holes in affected bones, inserting needles or cannulas for washing with a biocompatible fluid, and introducing bone growth-promoting materials, which includes using multiple needles or cannulas to improve distribution and retention of therapeutic agents, reducing leakage and enhancing bone healing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If a single needle or cannula is used for washing and injecting, then the procedure is simpler, but the distribution and retention of therapeutic agents is insufficient
Solution Approach 1:
The patent divides the single needle/cannula into multiple needles or cannulas (typically 2-4) that are inserted into different locations within the bone. This segmentation allows for better distribution of therapeutic agents throughout the bone tissue, improving both the quantity and uniformity of agent delivery while maintaining relative procedural simplicity through standardized insertion techniques.
2Quantity of substance
If multiple needles or cannulas are used, then the distribution and retention of therapeutic agents is improved, but the device complexity increases
Solution Approach 1:
The patent employs multiple needles or cannulas that all serve the same dual function: washing out necrotic tissue and delivering therapeutic agents. This multi-functionality approach improves agent distribution without requiring complex specialized devices for each function, thereby limiting the increase in device complexity.
Solution Approach 2:
The patent combines the washing function and therapeutic agent delivery function into a single integrated process using the same multiple needles or cannulas. This merging of functions improves efficiency and retention of therapeutic agents while avoiding the need for separate complex delivery systems.
3Reliability
If washing is performed to remove necrotic tissue, then bone healing is improved, but therapeutic agents may leak out
Solution Approach 1:
The patent performs the washing step first to remove necrotic tissue and create a clean environment for bone healing, then subsequently introduces therapeutic agents. This preliminary action ensures that the washing process does not cause agent leakage, as the agents are introduced after the washing is complete and the bone is prepared to retain them.
Solution Approach 2:
The patent maintains continuous presence of therapeutic agents in the bone by using multiple needles or cannulas that can simultaneously or sequentially deliver agents, ensuring that the beneficial effects are sustained without interruption or leakage, thereby improving bone healing reliability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach effectively removes dead cell debris and inflammatory factors, creates space for bone growth agents, and improves bone healing by minimizing leakage and enhancing the distribution and retention of therapeutic agents within the bone.
Implementation Method 1
washing an interior of the bone with a washing fluid introduced through one or more of the needles or cannulas inserted into the bone
Implementation Method 2
the washing fluid is a biocompatible isotonic fluid and optionally comprises biocompatible detergents, biocompatible surfactants, biocompatible alcohols
Implementation Method 3
introducing one or more bone growth promoting materials into the bone
Implementation Method 4
a bone morphogenic cytokine, bone morphogenic protein, a bone morphogenic protein-2 (BMP-2)
Data Source
AI summary
The present invention includes a method and devices for treating osteonecrosis in, e.g., children, adolescents, and adults comprising: identifying a subject in need of treatment for osteonecrosis; drilling two or more holes into a bone in need of treatment for osteonecrosis; inserting two or more needles or cannulas into the holes in the bone; washing an interior of the bone with a washing fluid introduced through one or more of the needles or cannulas inserted into the bone; and after washing the interior of the bone introducing one or more bone growth promoting materials or cells into the bone.