Multi-Omics Responder Classification for Personalized Skincare Regimens

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Solution Overview

Problem

Existing skincare treatments lack accuracy in determining responder categories for individuals, leading to suboptimal treatment outcomes due to insufficient use of omics data and dynamic responder category changes over time.

Innovation Solution

A computing system utilizing classifiers for various types of omics data to determine responder categories, which are updated based on clinical signs of aging and skincare regimen measurements, to improve treatment outcomes by personalizing skincare regimens.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional skincare treatments are used without omics data analysis, then the treatment approach is simple and easy to implement, but the accuracy in determining responder categories is low leading to suboptimal treatment outcomes

Engineering Contradiction:
Improveaccuracy in determining responder categoriesVSAvoidcomplexity of omics data analysis system
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The patent segments the complex omics data analysis into multiple independent classifiers, each handling a specific type of omics data (genomics, transcriptomics, proteomics, metabolomics, microbiomics). This segmentation allows the system to process different data types separately and combine results, reducing the complexity burden while maintaining high accuracy in responder category determination.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent introduces classifier models as intermediary components between raw omics data and responder category determination. These classifiers act as mediators that transform complex multi-omics data into actionable predictions, enabling accurate responder categorization without requiring direct complex analysis of all omics data simultaneously.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If static responder categories are used, then the classification process is simple, but the accuracy decreases due to dynamic changes in responder categories over time

Engineering Contradiction:
Improveaccuracy of responder category determinationVSAvoidtime for repeated measurements and updates
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The patent implements dynamic responder category determination by continuously updating classifier models with new omics data and clinical measurements over time. The system transitions from static classification to dynamic adaptation, where responder categories evolve as the subject's biological state changes, maintaining high accuracy without requiring excessive repeated measurements.

Inventive Principle:
Principle #15Dynamics

Solution Approach 2:

The patent incorporates feedback mechanisms where clinical measurements and treatment outcomes are fed back into the classifier models to update and refine predictions. This feedback loop allows the system to learn from actual treatment responses and improve future predictions, reducing the need for frequent re-measurements while maintaining accuracy.

Inventive Principle:
Principle #23Feedback

3Reliability

If personalized skincare regimens are developed using omics data, then treatment outcomes are improved, but the complexity of regimen customization increases

Engineering Contradiction:
Improveskincare treatment outcomesVSAvoidcomplexity of personalized regimen development
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent creates a universal platform with multi-functional classifiers that can handle multiple types of omics data and apply to various skincare treatment scenarios. This universal system reduces the complexity of developing personalized regimens by providing a standardized framework that works across different data types and treatment contexts, rather than requiring separate custom solutions for each case.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS12406771B2Predicting efficacies and improving skincare treatment outcomes based on responder/non-responder information
Publication Date: 2025.09.02 LOREAL SA
  • US12406771B2 patent drawing
  • US12406771B2 patent drawing
  • US12406771B2 patent drawing

AI summary

In some embodiments, techniques for improving treatment outcomes are provided. A computing system measures at least one skin condition for a subject. The computing system receives a plurality of types of omics data for the subject. For each type of omics data, the computing system uses at least one classifier associated with the type of omics data to determine whether the subject is in at least one responder category. The computing system predicts treatment outcomes for the at least one skin condition for the subject for a plurality treatments based on the at least one responder category. The computing system determines a skincare regimen based on the predicted treatment outcomes.