Multi-phase Oral Composition for Controlled Active Agent Delivery
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Solution Overview
Problem
Current dental products face limitations in delivering active agents effectively due to increased side effects from high concentrations and regulatory restrictions on bleaching agents, necessitating a more efficient and safer method for oral care.
Innovation Solution
A multi-phase oral composition comprising an aqueous phase with a hydrophobic phase, where the hydrophobic phase is in predominant proportion, allowing for the delivery of active agents at low concentrations with enhanced efficacy and reduced side effects, using a water-in-oil emulsion that can be applied via strips or trays, and is designed to minimize tooth sensitivity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the level of active agent in the composition is increased to improve efficacy, then the therapeutic effect is enhanced, but side effects increase and regulatory compliance becomes difficult
Solution Approach 1:
The composition is divided into two distinct phases: an aqueous phase containing the active agent and a hydrophobic phase. This segmentation allows the active agent to be delivered in a controlled manner through the aqueous phase while the hydrophobic phase provides a stable matrix that prevents excessive release, thereby reducing side effects while maintaining efficacy.
Solution Approach 2:
The hydrophobic phase acts as an intermediary between the active agent and the oral environment. It controls the release of the active agent from the aqueous phase, ensuring that effective concentrations are delivered to the teeth while preventing excessive amounts that would cause side effects or regulatory issues.
2Reliability
If the level of active agent in the composition is increased to improve efficacy, then the therapeutic effect is enhanced, but regulatory compliance is compromised
Solution Approach 1:
By segmenting the composition into aqueous and hydrophobic phases, the patent enables compliance with regulatory limits on active agent concentration in the overall composition while still achieving effective delivery to the teeth through the controlled release mechanism of the aqueous phase.
3Ease of manufacture
If a single-phase composition is used for simplicity, then the formulation is easier, but the delivery efficacy is reduced
Solution Approach 1:
The patent employs a composite formulation combining an aqueous phase with a hydrophobic phase. This composite structure enhances the delivery efficacy by providing both the active agent carrier (aqueous phase) and a stable release matrix (hydrophobic phase), while the formulation process remains straightforward using standard emulsification techniques.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-phase composition effectively delivers active agents at low concentrations, reducing side effects and compliance with regulatory limits, while maintaining high bleaching efficacy and stability, as demonstrated by the composition's ability to achieve significant whitening results with minimal active agent exposure.
Implementation Method 1
The present invention relates to multi-phase oral compositions for delivering active agents... comprising an aqueous phase... and a hydrophobic phase... wherein the hydrophobic phase may be in predominant proportion relative to the aqueous phase
Data Source
AI summary
A multi-phase oral composition for delivering active agents.