Multi-Station Hydrodynamic Catheter for Thrombolytic Penetration
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Solution Overview
Problem
Existing thrombectomy procedures are time-consuming due to the slow penetration of thrombolytic drugs into blood clots, which can take hours or days, and result in inefficient interaction with the clot adjacent to the blood vessel wall.
Innovation Solution
A catheter system with a multi-station hydrodynamic catheter design, featuring an outer catheter with multiple orifice stations and an inner catheter with fluid delivery ports, allowing for direct pressurized delivery of thrombolytic drugs along the length of the clot, enhancing penetration and interaction with the clot.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If thrombolytic drugs are delivered via weeping at low pressure, then the catheter system is simple to operate, but the penetration depth into the blood clot is insufficient and procedure time is extended
Solution Approach 1:
The catheter system transitions from static low-pressure weeping to dynamic high-pressure jet delivery. The inner catheter can be moved between positions to selectively engage with different portions of the blood clot, enabling dynamic adaptation to the clot's structure and size while maintaining high-pressure delivery for rapid penetration.
Solution Approach 2:
The catheter is divided into an outer catheter with orifice stations and an inner catheter with fluid delivery ports. This segmentation allows the system to deliver thrombolytic drugs at multiple locations along the blood clot simultaneously, increasing penetration depth and reducing procedure time while maintaining operational simplicity through coordinated movement of the inner catheter.
2Device complexity
If thrombolytic drugs are delivered at low pressure over hours or days, then the catheter system requires minimal pressure control, but the interaction effectiveness with the blood clot is reduced
Solution Approach 1:
The system changes the pressure parameter from low-pressure weeping (below 0.28 bar) to high-pressure jet delivery. The one or more orifices are configured to generate a fluid jet at high pressure, significantly enhancing the penetration depth and interaction effectiveness with the blood clot while the pressure control remains manageable through the catheter's designed orifice structure.
3Device complexity
If a single orifice station is used, then the catheter structure is simple, but the coverage along the blood clot is limited
Solution Approach 1:
The outer catheter is divided into multiple orifice stations positioned along its length, with the inner catheter containing fluid delivery ports that can be moved between positions. This segmentation enables the system to cover multiple sections of the blood clot simultaneously or sequentially, increasing coverage area while the structured arrangement of orifices maintains reasonable structural complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly reduces procedure time and enhances the effectiveness of thrombectomy by ensuring quicker interaction of thrombolytic drugs with the clot, facilitating faster breakdown and removal.
Implementation Method 1
the one or more orifices at the first orifice station are configured to generate a first fluid jet and the one or more orifices at the second orifice station are configured to generate a second fluid jet distal to the first fluid jet
Implementation Method 2
A catheter system with a multi-station hydrodynamic catheter design, featuring an outer catheter with multiple orifice stations and an inner catheter with fluid delivery ports, allowing for direct pressurized delivery of thrombolytic drugs along the length of the clot
Data Source
Figure 1~4
Figure 2~3A
Figure 3B~5
AI summary
A multi-station hydrodynamic catheter includes an outer catheter having a first lumen, the outer catheter having a plurality of orifice stations positioned along a portion of the outer catheter, where each orifice station includes one or more orifices extending from an outer catheter external surface to the first lumen. The multi-station hydrodynamic catheter includes an inner catheter having a second lumen, the inner catheter movable within the first lumen and includes at least one emanator, where the at least one emanator includes one or more fluid delivery ports extending from an inner catheter external surface to the second lumen.