Multi-Strain Bacillus Composition for Phytonematode Control

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Solution Overview

Problem

Existing chemical nematicides for phytonematode control are inefficient, pose environmental and health risks, and can lead to resistance, while single-microorganism biological controls have limited mechanisms of action.

Innovation Solution

A composition comprising Bacillus subtilis, Bacillus licheniformis, and Bacillus amyloliquefaciens, with additives and excipients, utilizing multiple mechanisms such as antibiosis, egg parasitism, and reduced phytonematode orientation, to enhance control efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If chemical nematicides are used for phytonematode control, then nematode population reduction is achieved, but environmental contamination and health risks increase

Engineering Contradiction:
Improvenematode control efficacyVSAvoidenvironmental contamination and health risks
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces chemical nematicides with a biological control system consisting of multiple bacterial strains (Bacillus subtilis, Bacillus licheniformis, Bacillus amyloliquefaciens) that produce nematicidal compounds through biological mechanisms, eliminating the need for synthetic chemicals and their associated environmental and health hazards

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The invention uses a composite biological formulation combining three different bacterial strains, each contributing different mechanisms of action (antibiosis, egg parasitism, reduced orientation), to achieve comprehensive nematode control while maintaining environmental safety

Inventive Principle:
Principle #40Composite materials

2Object-affected harmful factors

If single-microorganism biological controls are used, then environmental safety is improved, but control efficacy is limited

Engineering Contradiction:
Improveenvironmental safetyVSAvoidcontrol efficacy
Core Design Contradiction:
Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent merges three different bacterial strains into a single formulation, combining their complementary mechanisms of action (antibiosis from Bacillus subtilis, egg parasitism from Bacillus licheniformis, and reduced orientation from Bacillus amyloliquefaciens) to achieve superior control efficacy while maintaining environmental safety

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The composite bacterial formulation performs multiple functions simultaneously: direct nematicidal action, egg parasitism, and disruption of nematode orientation and migration, providing broad-spectrum control against various phytonematode species

Inventive Principle:
Principle #6Universality (Multi-functionality)

3Reliability

If chemical nematicides are used, then nematode population is reduced, but resistance development occurs

Engineering Contradiction:
Improvenematode population reductionVSAvoidresistance to chemicals
Core Design Contradiction:
ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent changes the mechanism of action from synthetic chemical nematicides to biological nematicidal compounds produced by bacteria, which have different modes of action that nematodes are less likely to develop resistance against, thereby maintaining long-term control efficacy

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition provides a safer, more effective alternative to chemical nematicides, offering broad-spectrum action, reducing phytonematode resistance, and maintaining crop productivity with reduced population and increased growth promotion.

Implementation Method 1

Antagonism is usually the predominant action of bacteria. In addition to the direct effect on the mortality of phytonematodes, such nematicidal compounds can act directly on the emergence of eggs or mobility of nematodes

Methodology Applied
Scientific EffectAntibiosis:

Implementation Method 2

mechanisms of action such as antagonism and parasitism have been widely used in commercial products

Methodology Applied
Scientific EffectEgg parasitism:

Implementation Method 3

such nematicidal compounds can act directly on the emergence of eggs or mobility of nematodes, and also cause indirect effects such as changes in root exudates or induction of resistance

Methodology Applied
Scientific EffectChanges in root exudates:

Data Source

PatentEP3841881B1Composition for biological control of phytonematodes
Publication Date: 2025.08.13 AGRIVALLE BRASIL IND E COMERCIO DE PROD AGRI LTDA

AI summary

The invention relates to a composition for the biological control of phytonematodes, and particularly to a composition of bacteria with nematicidal effects in damage mitigation and control of phytonematodes on cultivable plants. Pertaining to the technical field of biotechnology, this composition increases the specific efficiency of these microorganisms by means of mechanisms performing different and complementary actions. Particularly, the composition is a formulation containing quantities of Bacillus subtilis or the mutants thereof, Bacillus licheniformis or the mutants thereof, Bacillus amyloliquefaciens or the mutants thereof, together with additives and excipients, in biological compositions with nematicidal properties for controlling phytonematodes in plants.