Multi-Strain Probiotic Composition for Microbiome Diversity
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Solution Overview
Problem
Current probiotic products lack sufficient evidence to effectively increase intestinal microbial diversity and improve health outcomes, with many combination products lacking clinical evidence for their effectiveness in reducing dysbiosis and related symptoms.
Innovation Solution
A multi-strain probiotic composition comprising Bifidobacterium lactis, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, and Lactobacillus paracasei, which enhances intestinal microbiome diversity, improves the Firmicutes/Bacteroidetes ratio, and encourages growth of beneficial bacteria associated with health, thereby addressing dysbiosis and related conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple probiotic strains are combined in a single product, then the potential to increase microbial diversity and improve health outcomes is enhanced, but the clinical evidence supporting the effectiveness of such combination products is insufficient
Solution Approach 1:
The patent combines five specific probiotic strains (Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Bifidobacterium lactis, and Lactobacillus paracasei) into a single multi-strain composition. This merging of multiple beneficial bacterial strains aims to create a synergistic effect that increases intestinal microbial diversity and provides broader health benefits compared to single-strain products.
Solution Approach 2:
The patent specifies precise parameters for each probiotic strain including colony-forming units (CFU) ranges, pH stability requirements, and storage conditions. By controlling these parameters, the patent ensures that each strain maintains its viability and therapeutic effectiveness, thereby providing reliable clinical results despite the complexity of the multi-strain formulation.
2Quantity of substance
If probiotics are used to colonize and add to the diversity of the microbiome, then health benefits may be achieved, but there is a lack of sufficient evidence to support the idea that probiotics can effectively alter the microbiome composition
Solution Approach 1:
The patent provides detailed pre-clinical characterization of each probiotic strain's properties, including growth conditions, metabolic activities, and interactions with the gut environment. This preliminary characterization ensures that when the probiotics are administered, they are pre-optimized for effective colonization and microbiome modulation, increasing the likelihood of achieving measurable health benefits.
Solution Approach 2:
The patent incorporates mechanisms to monitor and assess the effectiveness of the probiotic composition, including markers for microbiome changes, inflammatory markers, and clinical outcome measures. This feedback approach allows for verification that the probiotics are indeed altering the microbiome composition and producing the intended health effects.
3Productivity
If high quantities of multiple probiotic strains are used, then the potential to improve gastrointestinal health and reduce symptoms is increased, but the complexity of the formulation and manufacturing process increases
Solution Approach 1:
The patent creates a composite probiotic formulation by combining five different bacterial strains in specific ratios and concentrations. This composite approach allows each strain to contribute its unique beneficial properties, creating a synergistic effect that enhances overall gastrointestinal health outcomes while maintaining a manageable formulation structure through defined composition parameters.
Data Source
AI summary
A probiotic composition is provided. The probiotic composition comprises different probiotic strains. The probiotic composition generally comprises: Bifidobacterium lactis; Lactobacillus acidophilus; Lactobacillusplantarum; Lactobacillus rhamno-sus; and Lactobacillusparacasei. The composition comprising suchprobiotic strains has abeneficial effect onthe intestinal microbiome diversity, improves the Firmicutes/Bacteroidetes ratio, and encourages growth of beneficial microbiota not contained in the composition itself. Also provided herein are uses of the probiotic composition.