Multi-substituted Hydroxyapatite Bone Substitute
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Solution Overview
Problem
Current bone substitutes made from stoichiometric hydroxyapatite are not biocompatible and biomimetic enough to effectively integrate and replace natural bone tissue, leading to slow integration and regeneration times due to insufficient osteoblast activation and reabsorbability issues.
Innovation Solution
Development of hydroxyapatite multi-substituted with Sr2+ ions and optionally silicate and/or carbonate ions, optimized to achieve specific molar ratios for enhanced biocompatibility and biomimicry, combined with a biohybrid composite using natural or synthetic polymers like collagen for improved bone tissue integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If stoichiometric hydroxyapatite is used as bone substitute, then material stability is maintained, but reabsorbability and osteogenesis are insufficient leading to slow bone integration
Solution Approach 1:
The patent applies parameter changes by substituting ions in the hydroxyapatite crystal structure with different elements (Sr, Si, Mg, CO3) to modify its chemical composition and physical properties. This enables the material to achieve both improved reabsorbability and osteogenesis while maintaining sufficient structural stability for bone substitution applications
2Reliability
If stoichiometric hydroxyapatite is used as bone substitute, then material simplicity is maintained, but osteoblast activation is insufficient leading to slow bone regeneration
Solution Approach 1:
The patent employs composite materials by creating multi-substituted hydroxyapatite containing multiple ion types (Sr2+, SiO4 4-, Mg2+, CO3 2-) within the hydroxyapatite structure. This composite approach at the atomic level provides synergistic effects that enhance osteoblast activation and bone regeneration while maintaining a single-phase material structure
3Productivity
If multi-substituted hydroxyapatite is developed to improve biocompatibility, then bone integration speed is enhanced, but manufacturing complexity increases
Solution Approach 1:
The patent applies preliminary action by pre-calculating and optimizing the molar ratios of substituting ions before synthesis. The specific molar ratios (Sr/Ca: 0.01-0.50, Si/PO4: 0.01-0.10, Mg/Ca: 0.01-0.20, CO3/PO4: 0.05-0.30) are determined in advance to achieve the desired biological performance, simplifying the manufacturing process by eliminating the need for iterative optimization
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-substituted hydroxyapatite and biohybrid composite demonstrate enhanced reabsorbability, osteogenesis, and structural similarity to natural bone, facilitating faster bone remodeling and integration, thus serving as an effective and biocompatible bone substitute.
Implementation Method 1
hydroxyapatite multi-substituted with physiologically compatible ion species... Sr2+, and optionally silicate (SiO4 4-) and/or carbonate (CO3 2-) ions
Data Source
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AI summary
The present invention relates to a hydroxyapatite multi-substituted with, physiologically compatible ion species and to its biohybrid composite with a natural and/or synthetic polymer, which are useful in the preparation of a biomimetic bone substitute for treat¬ ing bone tissue defects. Furthermore, the present invention relates to a method for their preparation and uses .