Multi-target Electrical Stimulation Circuit for Brain Wave Phase Locking
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Solution Overview
Problem
Existing brain stimulation technologies, such as RNS, can only achieve electrical stimulation of two key brain regions and cannot synchronize or sequentially stimulate multiple targets at fixed time intervals, limiting their effectiveness in treating functional brain diseases that involve abnormal networks across multiple neural circuits.
Innovation Solution
A multi-target electrical stimulation circuit with a control module, brain wave acquisition modules, and stimulation adjustment modules, where each electrode is configured with a corresponding acquisition and adjustment module, allowing for the acquisition of brain wave signals, phase locking, and synchronized or sequential stimulation of multiple targets at preset waveform phase points.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If a depth electrode is implanted in an epileptic focus for RNS stimulation, then electrical stimulation of two key brain regions can be achieved, but the system cannot achieve whole brain regulation of functional brain diseases involving multiple neural circuits
Solution Approach 1:
The patent divides the brain into multiple target regions (first target region and second target region) and assigns separate electrodes and control circuits to each region. This segmentation allows independent control and stimulation of multiple neural circuits simultaneously, enabling whole brain regulation while maintaining manageable system complexity through modular architecture
Solution Approach 2:
The control module is designed to universally manage multiple electrodes and stimulate different brain regions based on detected abnormal brain waves. The system can adaptively switch between stimulating different target regions depending on which abnormal activity is detected, providing multi-functional capability for regulating various neural circuits involved in functional brain diseases
2Ease of operation
If RNS stimulates two targets, then electrical stimulation can be provided to key brain regions, but time-locked matching cannot be achieved between the two targets
Solution Approach 1:
The system continuously detects abnormal brain waves from multiple brain regions and uses this real-time feedback to trigger stimulated responses. When abnormal activity is detected in a target region, the control module automatically initiates stimulation of that region and can coordinate stimulation of other regions based on the detected patterns, achieving time-locked matching through closed-loop feedback control
Solution Approach 2:
The system pre-configures multiple electrodes at different brain regions and establishes stimulation parameters in advance. When abnormal brain waves are detected, the pre-positioned electrodes can immediately deliver synchronized or sequential stimulation without delay, achieving precise time-locked matching between multiple targets through preliminary positioning and parameter setup
Data Source
AI summary
The present invention relates to a multi-target electrical stimulation circuit, an electrical stimulator, and a signal output method of the electrical stimulator. The electrical stimulation circuit includes a control module, a plurality of brain wave acquisition modules and a plurality of stimulation adjustment modules. Each electrode is correspondingly provided with one brain wave acquisition module and one stimulation adjustment module, and different electrodes are used for stimulating different targets. The brain wave acquisition modules are used for acquiring brain wave signals in the corresponding electrodes and transmitting the brain wave signals to the control module. The control module is used for acquiring brain rhythm phase signals according to the received brain wave signals and outputting stimulation signals at preset waveform phase points after phase locking of the brain rhythm phase signals. The stimulation adjustment modules are used for adjusting brain wave stimulation signals output to the corresponding electrodes according to the received stimulation signals. The multi-target electrical stimulation circuit, the electrical stimulator and the signal output method provided by the present invention are beneficial for achieving electrical stimulation of a plurality of targets as well as time-locked matching of electrical stimulation of a plurality of targets.