Multi-treatment Planning Apparatus with Antigen Filter

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Solution Overview

Problem

In combination treatment scenarios, optimizing each modality in isolation often results in sub-optimal outcomes due to initial damage or sensitization induced by the first treatment modality, making it challenging to achieve maximum therapeutic effect while minimizing side effects on non-target tissues.

Innovation Solution

A treatment modeler is used to model the effects and interactions between multiple treatment modalities, generating a treatment protocol that considers the synergistic, antagonistic, or other interactions between modalities, and employs a filter apparatus with antigens to remove treatment agents from bodily fluids, ensuring optimal application of multiple treatment modalities.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If each treatment modality is optimized in isolation, then the optimization process is simple and manageable, but the treatment outcome is sub-optimal due to interactions between modalities

Engineering Contradiction:
Improvetreatment optimization precisionVSAvoidtreatment planning complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The treatment planning system segments the optimization process into multiple stages: first optimizing individual modalities separately, then integrating them with interaction models. This allows manageable step-by-step optimization while ultimately achieving comprehensive multi-modality optimization that accounts for interactions between treatments.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

An interaction model serves as an intermediary between individual modality optimizations and the final combined treatment plan. This intermediary component captures the effects of treatment interactions (such as sensitization from first modality to second modality) and uses this information to adjust the optimization, resolving the contradiction between simple individual optimization and complex interaction-aware optimization.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If the interaction between treatment modalities is considered, then the treatment outcome is optimized, but the computational complexity and time required increase

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidtreatment planning time
Core Design Contradiction:
ReliabilityVSLoss of time

Solution Approach 1:

The system performs preliminary optimization of individual modalities before integrating interaction effects. By pre-optimizing each modality separately and then applying interaction adjustments, the system reduces the computational burden of full simultaneous optimization while still achieving interaction-aware results, thus reducing planning time without sacrificing treatment effectiveness.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system implements partial interaction modeling rather than complete exhaustive optimization. It considers the most significant interactions (such as sensitization effects) while approximating or omitting less critical interaction terms, achieving a balance between comprehensive optimization and computational efficiency that reduces planning time while maintaining treatment reliability.

Inventive Principle:
Principle #16Partial or excessive action

3Reliability

If the interaction between treatment modalities is considered, then the treatment outcome is optimized, but the complexity of the treatment protocol increases

Engineering Contradiction:
Improvetreatment effectivenessVSAvoidtreatment protocol complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The interaction model acts as an intermediary that translates complex multi-modality interactions into adjusted parameters for individual modalities. This allows the final treatment protocol to maintain a relatively simple structure (individual modality plans) while the intermediary interaction model handles the complexity of combining them, thus achieving optimized treatment effectiveness without excessively increasing protocol complexity.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The system optimizes treatment by adjusting parameters of individual modalities based on interaction effects, rather than creating entirely new complex protocols. By modifying doses, timing, or other parameters of existing modalities to account for interactions, the system achieves optimized effectiveness while maintaining protocol simplicity and manageability.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach allows for the generation of a treatment protocol that optimizes the therapeutic effect while minimizing side effects by considering the interactions between treatment modalities and effectively managing the presence of treatment agents in the body, leading to improved treatment outcomes.

Implementation Method 1

a filter apparatus with antigens to remove treatment agents from bodily fluids

Methodology Applied
Scientific EffectAntigen-antibody binding: Adsorption

Data Source

PatentUS10521563B2Multi-treatment planning apparatus and method
Publication Date: 2019.12.31 ELEKTA AB
  • US10521563B2 patent drawing
  • US10521563B2 patent drawing
  • US10521563B2 patent drawing

AI summary

A treatment planning apparatus includes a treatment modeler. The treatment modeler uses models of a plurality of treatment modalities in a treatment space to generate a treatment protocol that includes one or more the modalities in the treatment space. In one implementation, a treatment modality includes the removal of targeted treatment agents from an object.