Multi-Virus Chewing Gum Assembly for Oral Microbiome Mitigation
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Solution Overview
Problem
Existing methods fail to effectively mitigate the transmission of virus-related diseases and activate pre-immunity against future pandemics by targeting the oral-, shared oronasal, and orotracheal microbiome, particularly in response to climate-induced stress events that trigger general stress responses in archaea and protobacteria.
Innovation Solution
A chewing gum composition containing Komagatella phaffii, phytohaemagglutinin, and nanoscale zero-valent iron particles is designed to disrupt syntrophic methanogenic processes, reducing virus multiplication and stimulating immune responses by clearing virion particles and methanogenic bacteria from the oral cavity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to mitigate virus transmission, then general public health measures are implemented, but they fail to effectively target the oral microbiome and activate pre-immunity against future pandemics
Solution Approach 1:
The chewing gum delivers immune-stimulating compounds (beta-glucans, polysaccharides) in advance of potential virus exposure, activating the immune system's pre-immunity responses before pandemics occur. This preliminary immunostimulation prepares the body to respond more effectively to future viral threats.
Solution Approach 2:
The invention specifically extracts and targets methanogenic bacteria (Methanobrevibacter oralis, Methanocella sp.) from the oral microbiome using antimicrobial compounds (zinc undecylenate, zinc laurate). By removing these specific pathogenic components while preserving beneficial microbes, the system achieves targeted mitigation without disrupting the entire microbiome ecosystem.
2Object-affected harmful factors
If the oral microbiome is disrupted to eliminate methanogenic bacteria, then virus multiplication is reduced and breath is sanitized, but the overall microbiome balance may be affected
Solution Approach 1:
The chewing gum applies different functional components to different microbial targets: zinc undecylenate and zinc laurate specifically target methanogenic bacteria, while probiotic strains (Lactobacillus acidophilus, Bifidobacterium animalis) replenish beneficial microbes. This localized differentiation eliminates pathogens while preserving and restoring microbiome balance.
Solution Approach 2:
The invention converts the potentially harmful effect of microbiome disruption into a benefit by using the disruption opportunity to deliver beneficial probiotics simultaneously. The antimicrobial action against methanogens creates space and opportunity for beneficial bacteria to colonize, transforming a negative effect into a positive microbiome restructuring.
3Reliability
If immune-stimulating compounds are delivered through chewing gum, then pre-immunity is activated and susceptibility to virus infection is reduced, but the complexity of the composition increases
Solution Approach 1:
The chewing gum serves multiple functions simultaneously: it delivers immune-stimulating compounds (beta-glucans, polysaccharides from Saccharomyces cerevisiae), provides probiotics for microbiome restoration, and includes antimicrobials for pathogen elimination. This multi-functionality consolidates several health benefits into a single product, managing complexity through integration rather than separation.
Solution Approach 2:
The invention merges multiple active ingredients (probiotics, prebiotics, antimicrobials, immune stimulants) into a single chewing gum matrix. By combining these components in one deliverable system rather than requiring separate products, the invention manages composition complexity while achieving synergistic health effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The chewing gum composition effectively reduces susceptibility to virus infections, collects virions, and stimulates anti-viral immune responses, preventing the spread of viruses and associated diseases by sanitizing breath and eliminating infectious targets in the oral and gastrointestinal tract.
Implementation Method 1
a methylotrophic yeast, which is Komagatella phaffii, said Komagatella phaffii being provided in an amount of between 10^6 and 10^9 colony forming units (CFU) per chewing gum, said Komagatella phaffii being active for consuming methanol
Implementation Method 2
said phytohaemagglutinin being provided in an amount of between 1 and 10 microgram per chewing gum, said phytohaemagglutinin being capable of stimulating a T-cell and B-cell response
Implementation Method 3
said nanoscale zero-valent iron particles being provided in an amount of between 1 and 10 milligram per chewing gum, said nanoscale zero-valent iron particles being capable of aggregating virion particles and/or methanogenic bacteria
Data Source
Figure 1.0
Figure 1.1
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AI summary
The present invention relates to a method for a chewing-gum based mitigation of virus-related disease spread and pre-immunity activation based on disruption of syntrophic methanogenic processes in the oral-, shared oronasal and orotracheal microbiome. The invention provides a chewing gum composition comprising a methylotrophic yeast, preferably Komagatella phaffii; a plant lectin, preferably phytohaemagglutinin; and/or iron particles, preferably zero-valent iron particles.