Multi-Wavelength Liquid Assay Analysis for Faster Multi-Analyte Detection
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Solution Overview
Problem
Existing analyzers require prolonged time to read multiple analytes due to sequential measurements using limited wavelength ranges, which can be improved for faster and more efficient analysis.
Innovation Solution
An analyzer equipped with multiple light sources emitting distinct wavelength ranges and a detector system that simultaneously captures light signals to determine multiple analytes, using a processor to solve equations for analyte amounts based on calibration data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If sequential measurement using limited wavelength ranges is used, then device complexity is reduced, but measurement time increases
Solution Approach 1:
The patent segments the measurement process by assigning different wavelength ranges to different analytes. The first wavelength range (first wavelength) measures the first analyte, the second wavelength range (second wavelength) measures the second analyte, and the third wavelength range (third wavelength) corrects for interfering substances. This segmentation enables simultaneous measurement of multiple analytes, resolving the contradiction by reducing measurement time while maintaining manageable device complexity through structured wavelength assignment.
Solution Approach 2:
The patent implements multi-functionality by using a single optical system to perform multiple measurement functions simultaneously. The same detector and light source assembly measure multiple analytes (first analyte, second analyte) and correct for interfering substances (lipid, bilirubin) across different wavelength ranges, eliminating the need for separate measurement systems and reducing overall device complexity while achieving rapid simultaneous measurement.
2Productivity
If multiple wavelength ranges are used for simultaneous measurement, then measurement speed increases, but device complexity increases
Solution Approach 1:
The patent merges multiple measurement functions into a single integrated optical system. Instead of using separate systems for each wavelength range, the invention combines the first, second, and third wavelength measurements into one coordinated system with a single detector assembly, achieving high measurement speed while controlling device complexity through functional integration.
Solution Approach 2:
The patent utilizes parameter changes by varying the wavelength of light across three distinct ranges to differentiate between multiple analytes and interfering substances. By changing the wavelength parameter systematically (first wavelength for first analyte, second wavelength for second analyte, third wavelength for correction), the system achieves rapid simultaneous measurement without requiring complex additional hardware, thus improving productivity while managing device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables simultaneous determination of multiple analytes in a shortened time frame, enhancing the efficiency and speed of diagnostic assays.
Implementation Method 1
The first light source generates a first beam of light passing through the test cartridge space, the first beam of light having a first wavelength range. The second light source generates a second beam of light passing through the test cartridge space, the second beam of light having a second wavelength range different from the first wavelength range. The third light source generates a third beam of light passing through the test cartridge space, the third beam of light having a third wavelength range different from the first and second wavelength ranges.
Implementation Method 2
The at least one sample detector is positioned to receive one or more of the first, second and third beams of light subsequent to the first, second and third beams of light passing through the test cartridge space to generate first, second and third signals.
Implementation Method 3
a test cartridge containing a liquid test sample - reagent mixture configured to undergo an immunotype reaction
Data Source
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AI summary
Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.