Multi-Wavelength Photobiomodulation System for Complex Disease Treatment
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Solution Overview
Problem
Current treatments for complex diseases such as peripheral arterial disease, eye diseases, and solid tumors often result in partial or transient responses due to adaptation in molecular pathways, leading to progression or relapse, and lack effective methods for intermediate and late-stage tumors.
Innovation Solution
Non-invasive, dynamic, multi-wavelength, multi-node photobiomodulation therapy methods and systems that apply optical pulses to multiple anatomical locations on the body, including arteries, using fractal patterns and high-frequency modulation to reestablish physiologic rhythms and promote homeostasis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If single molecular target agents are used to treat complex diseases, then non-specific toxicity is avoided, but treatment effectiveness deteriorates due to disease adaptation and relapse
Solution Approach 1:
The patent divides the treatment approach into multiple independent light sources emitting at different wavelengths (e.g., 630-680nm, 780-810nm, 830-880nm, 904-945nm, 1064-1200nm). Each wavelength targets different molecular pathways and chromophores in the disease tissue, preventing adaptation to a single treatment mechanism while avoiding the toxicity of pharmacological agents.
Solution Approach 2:
The system dynamically adjusts multiple parameters including wavelength selection, pulse duration (nanosecond to millisecond ranges), repetition rates (1-15 MHz), and fluence levels. These parameter variations allow the treatment to adapt to different disease stages and tissue types, maintaining effectiveness without causing non-specific toxicity associated with fixed-dose pharmaceuticals.
2Device complexity
If conventional single-wavelength PBM is used, then treatment simplicity is maintained, but treatment effectiveness deteriorates for intermediate and late-stage tumors
Solution Approach 1:
The treatment system is segmented into multiple independent light sources, each emitting at a specific wavelength range targeting different photoreceptors and molecular pathways. This segmentation allows comprehensive coverage of disease processes in intermediate and late-stage tumors while maintaining individual source simplicity for clinical operation.
Solution Approach 2:
The system employs pulsed light delivery with specific repetition rates (1-15 MHz) and duty cycles that create periodic thermal and non-thermal effects. This periodic action enhances treatment effectiveness for advanced tumors by preventing thermal damage while maximizing photobiomodulation effects across multiple treatment cycles.
3Reliability
If high repetition rate optical pulses are applied, then physiologic rhythm reestablishment is improved, but energy consumption increases
Solution Approach 1:
The system uses pulsed light delivery with repetition rates of 1-15 MHz and duty cycles that allow tissue cooling between pulses. This periodic action reestablishes physiologic rhythms through synchronized photobiomodulation while minimizing thermal damage and energy consumption compared to continuous wave operation.
Solution Approach 2:
The pulsed light delivery creates controlled thermal phase transitions in tissue water, generating cavitation bubbles and shockwaves that enhance drug delivery and tissue permeability. These phase transitions occur during the high-power pulses while the lower power intervals allow thermal dissipation, optimizing energy efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides a non-invasive, effective treatment for complex diseases by reestablishing altered physiologic rhythms and promoting homeostasis, potentially offering sustained benefits for conditions like peripheral arterial disease, eye diseases, and solid tumors.
Implementation Method 1
non-invasively applying a first sequence of optical pulses comprising at least a first plurality of pulses of a first wavelength at a first repetition rate, and subsequently a second plurality of pulses of a second different wavelength at a second repetition rate
Data Source
AI summary
Noninvasive, dynamic, multi-wavelength, multi-pulse, multi-node photobiomodulation methods can be used to treat complex diseases (CDs), including, but not limited to cancer, diseases of the eye or brain, and arterial disease. Light is non-invasively provided to the skin of a body proximal a plurality of arteries. In various implementations, the optical signals applied to the body and/or the parameters of the regimen for applying the optical signals to the body are fractal in nature and/or are similar to or match fractals or characteristics of fractals in one or more biological signals, system, structures or processes.