Multi-Wavelength Sample Analyzer for Chyle Interference Correction
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Solution Overview
Problem
Conventional sample analyzers face challenges in accurately measuring hemoglobin and bilirubin concentrations due to interference from chyle, requiring separate sample preparation and measurement processes, which consume samples and are inefficient.
Innovation Solution
A sample analyzer that measures optical information at multiple wavelengths to exclude the influence of chyle, allowing for simultaneous measurement of hemoglobin and bilirubin concentrations without separate sample preparation, using a system with a light emitting part, light receiving part, and measuring means to determine coagulation time and interference substances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If a single wavelength absorbance measurement is used to estimate chyle interference, then the measurement process is simplified, but the measurement precision deteriorates because approximate expressions cannot accurately determine the unknown constants in the exponential function
Solution Approach 1:
The patent transitions from single-wavelength absorbance measurement to multi-wavelength absorbance measurement. By measuring absorbance at multiple wavelengths (at least three different wavelengths), the system gains additional dimensional data that enables accurate determination of the exponential function constants (a and b) through simultaneous equations, thereby resolving the precision issue while maintaining reasonable process complexity
Solution Approach 2:
The patent changes the measurement parameter from single-wavelength absorbance to multi-wavelength absorbance. This parameter change allows the system to obtain multiple absorbance values (A1, A2, A3 at wavelengths λ1, λ2, λ3) that can be used to solve for the unknown constants in the chyle absorbance exponential function, significantly improving estimation accuracy
2Measurement precision
If separate sample blank solution preparation is performed for interference substance measurement, then the measurement of hemoglobin and bilirubin不受chyle influence is achieved, but the productivity deteriorates due to separate measurement processes and sample consumption
Solution Approach 1:
The patent merges the interference substance measurement process with the main measurement process. By using the same sample for both chyle interference assessment and hemoglobin/bilirubin measurement, the system eliminates the need for separate sample blank preparation and parallel measurement processes, thereby improving productivity while maintaining measurement precision through mathematical correction
Solution Approach 2:
The patent makes the sample serve multiple functions: it is used both for assessing chyle interference and for measuring hemoglobin and bilirubin concentrations. This multi-functional use of the sample eliminates waste and improves efficiency, as the same sample provides data for both correction factor calculation and target substance measurement
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and efficient measurement of hemoglobin and bilirubin concentrations by minimizing the impact of chyle interference, reducing sample consumption and improving measurement reliability.
Implementation Method 1
measuring optical absorbance at several different wavelengths specific to each interference substances
Data Source
AI summary
A sample analyzer includes (a) a measuring part for measuring optical information of a sample at first wavelength, second wavelength, and third wavelength, first light of the first wavelength and second light of the second wavelength being absorbed by a second substance but substantially not absorbed by a first substance, and third light of the third wavelength being absorbed by the first substance; and (b) an obtaining part for obtaining content of the first substance in the sample, and content of the second substance in the sample, influence by the second substance being excluded from the content of the first substance, based on the optical information at the first wavelength, second wavelength, and third wavelength measured by the measuring part.