Multi-well Cuvette with Integrated Reaction and Detection
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Solution Overview
Problem
Conventional methods for analyzing biological samples face issues with cross-contamination, inaccurate sample loading, and the need for separate devices for reaction and detection, which complicates the process and increases costs.
Innovation Solution
A multi-well cuvette integrating a reaction part with collector and reagent chambers for sample-reagent interaction and an analysis part with a chromatographic system for detection, featuring a chromatographic cartridge for lateral flow assay, a separation member for removing unwanted materials, and a simple, serial arrangement of chambers for streamlined testing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If separate devices are used for reaction and detection, then functional specialization is achieved, but device complexity and cross-contamination risk increase
Solution Approach 1:
The patent combines the reaction chamber and detection chamber into a single integrated cuvette device. The reaction chamber contains sample and reagent compartments where biochemical reactions occur, while the detection chamber houses optical components for measuring reaction products. This merging eliminates the need to transfer samples between separate devices, thereby preventing cross-contamination while maintaining functional specialization through distinct chamber designs.
2Productivity
If multiple separate devices are used for sample collection, reaction, and detection, then each function can be optimized, but the number of steps and cost increase
Solution Approach 1:
The cuvette device performs multiple functions within a single unit: it collects samples in dedicated compartments, facilitates biochemical reactions in the reaction chamber with integrated mixing mechanisms, and conducts optical detection in the detection chamber. This multi-functional design consolidates what would traditionally require separate devices into one universal platform, reducing procedural steps and overall system complexity.
Solution Approach 2:
The integrated cuvette is divided into distinct functional segments including sample compartments, reagent compartments, a reaction chamber with mixing elements, and a detection chamber with optical pathways. This segmentation allows each function to be optimized independently within the integrated structure, enabling simultaneous sample handling, reaction, and detection without cross-interference.
3Measurement precision
If conventional separate device processes are used, then operational simplicity is maintained, but measurement accuracy and reproducibility decrease
Solution Approach 1:
The cuvette is pre-configured with all necessary reagents in separate compartments and integrated mixing mechanisms before the analysis begins. Sample and reagent mixing, reaction incubation, and detection are all prepared within the sealed cuvette structure, eliminating the need for multiple manual transfer steps that could introduce errors. This preliminary preparation ensures consistent reaction conditions and improves measurement precision.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This integrated approach simplifies the testing process, reduces cross-contamination, ensures accurate and rapid analysis, and lowers manufacturing costs by eliminating the need for separate devices, while allowing for convenient and reproducible detection of analytes.
Implementation Method 1
an analysis part for detecting a reaction product between the biological sample and the reagent comprising a chromatographic system and a detection chamber accommodating the chromatographic system
Implementation Method 2
at least one of the base member and the cover member comprise a structure for introducing the reaction product loaded in the sample receiving well to the strip by an capillary action
Data Source
AI summary
The present application discloses a multi-well cuvette for integrating the reaction between a sample and a reagent with the detection of a specific analyte included therein, and the multi-well cuvette comprises: a reaction chamber part having a sample and a reagent placed therein; and a detection part for detecting the reaction between the sample and the reagent, wherein the reaction chamber part comprises: an extraction member standby chamber in which a member for dividing or distributing the sample is on standby; a sample filling chamber; and a reagent filling chamber which is filled with the reagent, and in which the reaction with the sample is carried out, wherein the detection part comprises: a chromatography analysis means for a reactive product between the sample and the reagent; and a detection chamber for accommodating the same.