Multi-Well Tissue Modulation for Individualized Strain Profiling
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Solution Overview
Problem
Existing tissue modulating systems fail to apply individualized mechanical strains to multiple tissue specimens simultaneously, as they often expose all tissues to the same stimulus, and cannot adjust stimuli based on each specimen's physiological state or characteristics, limiting effective testing and conditioning.
Innovation Solution
A tissue modulating system with a multi-well plate configuration, featuring a first and second plurality of tissue fixtures with varying stiffness, and an actuator to independently modulate and stimulate multiple tissue specimens, allowing for individualized strain profiles and real-time feedback-based adjustments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a device applies mechanical stimulation to multiple tissues simultaneously, then productivity is improved, but the ability to apply individualized strain profiles to each tissue deteriorates
Solution Approach 1:
The device divides the stimulation system into independent channels, with each tissue specimen in a separate well receiving customized mechanical stimulation through its own actuator and fixture assembly, enabling parallel processing of multiple tissues with individualized protocols
Solution Approach 2:
The system employs adjustable fixtures with variable stiffness characteristics that can be dynamically configured for each tissue type, allowing the mechanical properties of the stimulation apparatus to be adapted to match the specific requirements of different tissue specimens
2Device complexity
If a device applies the same stimulus to all tissues, then device complexity is reduced, but measurement precision of individual tissue responses deteriorates
Solution Approach 1:
Each tissue specimen is equipped with dedicated measurement fixtures and sensors that are locally optimized for its specific characteristics, allowing precise measurement of individual tissue responses while maintaining a unified overall system architecture
3Adaptability or versatility
If fixtures have varying stiffness, then adaptability to different tissue types is improved, but device complexity increases
Solution Approach 1:
The system provides a library of fixtures with different stiffness parameters that can be selected and configured for each tissue type, allowing the mechanical properties to be adjusted to match tissue characteristics without requiring a completely different apparatus for each tissue
Data Source
AI summary
Tissue modulating systems, devices, and methods modulate and/or stimulate numerous tissue specimens, independently and in parallel, within a multi-well plate in such a way to allow simultaneous measurement of functional properties of the tissue specimens. Tissue modulating system includes a first plurality of tissue fixtures, with at least one of the first tissue fixtures extending into each well. The system also includes a tissue fixture modulating apparatus including a second plurality of tissue fixtures, with at least one of the second tissue fixtures extending into each well. The tissue fixture modulating apparatus displaces the second tissue fixture in each well.