Multi-Biotic Capsules with Varying Dissolution Rates
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Solution Overview
Problem
Current synbiotics often lack effective doses of prebiotics, do not include postbiotics due to unpleasant taste and odor, and fail to deliver components effectively to the gastrointestinal tract, leading to poor user compliance and inadequate gut health support.
Innovation Solution
Development of multi-biotic dietary supplements containing postbiotics, prebiotics, and probiotics, with varying dissolution rates in inner and outer capsules to ensure targeted delivery and improved taste masking, utilizing a probiotic blend including Bifidobacterium and Lactobacillus species, and prebiotic blends like Myoviridae bacteriophages, encapsulated in delayed and immediate-release capsules for optimal absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If postbiotics are included in synbiotics, then gut health support is improved, but unpleasant taste and odor decrease user compliance
Solution Approach 1:
The patent uses an intermediary substance (flavor masking agent or carrier) to deliver postbiotics while masking their unpleasant taste and odor. This allows the postbiotic components to provide gut health benefits without the sensory drawbacks that would otherwise reduce user compliance.
Solution Approach 2:
The patent extracts the problematic sensory properties (taste and odor) from the postbiotic formulation while retaining the beneficial gut health components. By separating or masking the unpleasant sensory aspects, the formulation maintains efficacy without compromising user acceptance.
2Reliability
If synbiotics contain probiotics and prebiotics, then microbiome modulation is improved, but prebiotic dose is insufficient for efficacy
Solution Approach 1:
The patent applies partial or excessive action by incorporating prebiotics in amounts that exceed the typical synbiotic formulations. This ensures sufficient prebiotic dose to achieve efficacy in microbiome modulation, moving beyond the partial action of conventional synbiotics that underdose prebiotics.
3Ease of operation
If multiple components are delivered in a single supplement, then convenience is improved, but component delivery to target locations becomes complex
Solution Approach 1:
The patent segments the supplement into distinct functional components (probiotics, prebiotics, postbiotics) with different delivery mechanisms. Each component is formulated to reach its specific target location in the gastrointestinal tract, managing complexity through functional segmentation while maintaining single-dose convenience.
Solution Approach 2:
The patent applies local quality by ensuring each supplement component is optimized for its specific target location in the GI tract. Different components have different dissolution rates and release characteristics tailored to their specific sites of action, allowing precise local delivery while remaining part of a unified supplement system.
4Reliability
If postbiotics are added to synbiotics, then comprehensive microbiome support is improved, but formulation complexity increases
Solution Approach 1:
The patent merges probiotics, prebiotics, and postbiotics into a single integrated supplement formulation. This combining approach provides comprehensive microbiome support while managing formulation complexity through unified manufacturing and delivery systems that handle all three components simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multi-biotic supplements enhance gut, digestive, and immune health by ensuring effective delivery of bioactive compounds to the gut microbiome, improving compliance through taste masking and targeted release, and demonstrating synergistic effects in butyrate production and gut barrier function.
Implementation Method 1
Each of the inner and outer capsules may have different dissolution or degradation rates
Data Source
AI summary
Described herein are multi-biotic supplements containing a mixture of postbiotics, prebiotics, and probiotics within nested capsules, for use in supporting the health of a subject, including gut health, digestive health, and immune health.