Multichannel DBS Electrodes for Simultaneous Stimulation and Recording
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Solution Overview
Problem
Current deep brain stimulation (DBS) devices lack the capability for simultaneous stimulation and signal reception, making it difficult to determine the location of implanted electrodes and optimize neuronal response, particularly for conditions like Parkinson's disease and epilepsy.
Innovation Solution
A system utilizing multichannel electrodes for electromagnetic stimulation and phase-sensitive detection, allowing for simultaneous neuromodulation and signal reception, with adjustable parameters like amplitude, frequency, and phase, and incorporating feedback loops for active control of stimulus placement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional DBS devices are used for neuromodulation, then stimulation can be delivered to the brain, but the location of implanted electrodes cannot be determined and neuronal response cannot be measured
Solution Approach 1:
The patent combines stimulation and recording functions into a single integrated device. The same electrodes that deliver electrical stimulation to the brain also record neuronal responses, eliminating the need for separate recording devices and enabling real-time feedback for determining electrode location and measuring neuronal activity.
Solution Approach 2:
The DBS device is designed with multi-functionality, serving both as a stimulator and a recorder. The electrodes can deliver electrical pulses for neuromodulation and simultaneously detect electrical signals from neurons, providing versatile functionality for both therapy delivery and diagnostic measurement.
2Measurement precision
If simultaneous stimulation and signal reception is implemented, then electrode location and neuronal response can be determined, but device complexity increases
Solution Approach 1:
By merging stimulation and recording functions into the same device and electrodes, the patent reduces overall system complexity. Instead of requiring separate stimulation devices and recording systems, a single integrated device performs both functions, simplifying the system architecture despite adding measurement capabilities.
3Reliability
If feedback-driven neuromodulation is implemented, then neuronal response can be optimized in real-time, but device complexity and control mechanisms increase
Solution Approach 1:
The patent implements feedback-driven neuromodulation where the recorded neuronal responses are used to adjust stimulation parameters in real-time. The system monitors neuronal activity through recorded signals and modifies stimulation delivery based on the observed responses, creating a closed-loop control system that optimizes therapeutic effect.
Solution Approach 2:
The device performs self-adjustment by using its own recorded signals to control its stimulation output. The system automatically analyzes the recorded neuronal responses and modifies stimulation parameters without requiring external intervention, enabling real-time optimization of neuronal response.
4Manufacturing precision
If multichannel electrodes with independent parameter control are used, then stimulation precision and neuronal response modulation improve, but device complexity increases
Solution Approach 1:
The patent divides the electrode system into multiple independent channels, each capable of delivering stimulation with independent parameters. This segmentation allows precise control over different neuronal populations or brain regions, enabling targeted neuromodulation while maintaining the ability to record from multiple locations simultaneously.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances the safety, efficiency, and simplification of neurosurgical procedures by enabling precise modulation of neuronal activity and improving the quality of DBS devices.
Implementation Method 1
utilization of electromagnetic (EM) stimulation in pulsed and/or continuous wave configurations for deep brain stimulation
Implementation Method 2
The stimulation may be combined with simultaneous reception of the neuronal response using phase sensitive detection
Data Source
AI summary
Systems and methods are provided for neuromodulation with simultaneous stimulation and reception of neuronal response. A closed-loop control system provides the ability to modulate any combination of at least five parameters of stimulation (magnitude, frequency, amplitude, time, and phase) based on any combination of at least five parameters of received signals. The neuromodulation is well-suited for deep brain stimulation (DBS) applications.