Multichannel Detection Device Signal Integrity
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Solution Overview
Problem
Current multichannel detection devices are bulky, limited in portability, and prone to liquid infiltration, which affects their efficiency and accuracy in measuring ion channel responses due to their discrete electronic architecture and lack of effective electromagnetic shielding.
Innovation Solution
A compact, high-sensitivity multichannel detection system with a separation of the 'wet' detection components from electronics and advanced electromagnetic shielding, utilizing a processing module with integrated ASIC processing channels and an FPGA processor, along with a containment enclosure made of conductive material and hydrophobic seals to prevent liquid infiltration and enhance signal/noise ratio.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If discrete electronic architecture is used for multichannel detection, then the device can be manufactured with conventional components, but the device becomes bulky and limited in portability
Solution Approach 1:
The patent integrates multiple processing channels into a single integrated circuit chip, merging discrete electronic components into one compact unit. This consolidation achieves multichannel detection functionality while dramatically reducing device size and improving portability, resolving the contradiction between manufacturability and portability.
2Ease of manufacture
If discrete electronic architecture is used, then the device can be assembled with standard components, but the number of simultaneously acquired channels is limited
Solution Approach 1:
The integrated circuit chip combines multiple processing channels in a single device, enabling simultaneous acquisition of multiple channels without the limitations of discrete component assembly. This merging approach directly increases productivity by enabling true multichannel parallel detection.
Solution Approach 2:
The integrated circuit serves multiple functions simultaneously - it processes signals from multiple sensors across multiple channels in parallel, making a single device universally capable of handling various detection tasks that would otherwise require multiple separate devices.
3Device complexity
If electronic components are placed close to sensor components, then the device structure is simplified, but liquid infiltration affects electronic components and reduces reliability
Solution Approach 1:
The device is segmented into distinct functional zones: a sensor component region that contacts liquids and an electronic component region that remains protected. This spatial segmentation allows the electronic components to be positioned away from liquid exposure areas, maintaining reliability while preserving a relatively simple overall device structure.
4Measurement precision
If conventional amplification equipment is used for ion channel detection, then the device can detect picoampere signals, but the device becomes bulky and expensive
Solution Approach 1:
The amplification function is merged into the integrated circuit chip itself, combining signal detection and amplification capabilities in a single compact unit. This eliminates the need for bulky external amplification equipment while maintaining the sensitivity required for picoampere signal detection, thereby reducing both device size and cost.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves high sensitivity and accuracy in measuring nano- or picoampere signals from sensors, enabling portable, efficient, and precise multichannel measurements while minimizing noise and preventing liquid infiltration into electronic components.
Implementation Method 1
hydrophobic seals to prevent liquid infiltration
Implementation Method 2
containment enclosure made of conductive material... to enhance signal/noise ratio
Implementation Method 3
processing channels being adapted to amplify and to filter the signals of said sensors
Implementation Method 4
amplifying the currents of the ion channels that are of the order of picoamperes
Data Source
AI summary
A detection device of a sample to be examined is described, including a processing module, a detecting module, connected to the processing module, a support, in which the sample to be examined can be placed, the support including a plurality of sensors, preferably biosensors and/or nanosensors, and being insertable within the detecting module, and a containment enclosure including a body, which is arranged within the processing module, and a sensor portion, in which the detecting module is arranged. The processing module includes a processing unit having a plurality of processing channels and a processor, each one of the processing channels being connected to one respective of the sensors and being adapted to amplify and to filter the signals of the sensors, the processor processing the signals amplified and filtered by the processing channels.