Multicompartment Capsule Divider for Drug Stability
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Solution Overview
Problem
Conventional capsules struggle to effectively deliver combination drug therapies due to stability issues and physical/chemical interactions between different drugs, leading to degradation products and inconsistent release profiles during manufacture and storage.
Innovation Solution
A multicompartment capsule design featuring a first and second hollow body that couple to form an interior volume, with a divider that partitions the space into unique compartments, preventing interaction between pharmaceutical compositions and ensuring stable delivery of multiple agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If multiple drugs are combined in the same capsule compartment, then the convenience of combination therapy is improved, but drug stability and purity deteriorate due to physical and chemical interactions between drugs
Solution Approach 1:
The capsule is divided into multiple separate compartments, each containing a different drug. This segmentation prevents direct contact between drugs, eliminating physical and chemical interactions while maintaining the convenience of combination therapy in a single capsule.
2Ease of operation
If multiple drugs are combined in the same capsule compartment, then the convenience of combination therapy is improved, but degradation products are generated due to drug interactions
Solution Approach 1:
By separating drugs into different compartments, the invention eliminates the conditions that lead to degradation product formation, while still providing the benefit of combination therapy convenience.
3Device complexity
If a single compartment capsule is used, then the device complexity is reduced, but the ability to deliver multiple drugs with different release profiles is limited
Solution Approach 1:
The capsule is divided into multiple compartments that can be independently designed with different release characteristics. Each compartment can contain drugs with different release profiles (immediate, sustained, controlled) without affecting the other compartments, providing versatility while maintaining relatively simple overall structure.
Solution Approach 2:
Multiple compartments are nested within the capsule structure, with each compartment containing specific drug formulations. This nested arrangement allows for complex drug delivery functionality within a relatively simple outer capsule structure.
4Ease of manufacture
If drugs are combined in the same compartment, then manufacturing simplicity is improved, but manufacturing precision deteriorates due to inconsistent drug distribution
Solution Approach 1:
The compartmentalization approach allows each drug to be separately filled into its designated compartment, ensuring precise and consistent drug distribution. This segmentation maintains manufacturing simplicity while dramatically improving drug distribution consistency compared to mixing multiple drugs in a single compartment.
Data Source
AI summary
Systems, methods, devices, and compounds for facilitating a capsule are provided. The capsule includes a first hollow body and a second hollow body configured to couple together, which collectively form an interior volume of the capsule. The capsule includes a divider that includes a base and a sidewall protruding from a first circumferential edge portion of the base. The sidewall includes an inner surface, an outer surface, and a second circumferential edge portion. The second circumferential edge portion is configured to continuously engage a unique circumferential surface of the capsule, which secures the divider within the interior volume of the capsule and forms at least two unique interior volumes based on a position of the t divider and the unique circumferential surface of the capsule. The capsule includes a plurality of pharmaceutical compositions, each of which occupies a unique interior volume in the at least two unique interior volumes.