Multicomponent Capsules With Spherical Tablets for Timed Release

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Solution Overview

Problem

Existing nutraceuticals in solid dosage forms often have poor bioavailability, ineffective targeting, and low gastrointestinal permeability, leading to a mismatch with endogenous metabolic or physiological rhythms.

Innovation Solution

A customized-release nutraceutical capsule comprising multiple spherical tablets, including extended and immediate release tablets, each with a coating and matrix containing a rate controlling polymer, designed to optimize delivery over an extended duration.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If simple solid dosage forms (instant release capsules, extended release tablets) are used, then manufacturing and packaging are simplified, but bioavailability and gastrointestinal permeability deteriorate

Engineering Contradiction:

Improvemanufacturing simplicityVSAvoidbioavailability

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The invention divides the single tablet into multiple spherical tablets (at least two) with different release characteristics (immediate release and extended release) that are combined in one capsule. This segmentation allows each spherical tablet to be optimized for specific release profiles while maintaining the simplicity of solid dosage form manufacturing and packaging.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention uses composite formulation approaches by combining different matrix materials and coating materials with specific properties (hydrophilic matrices, hydrophobic coatings, rate-controlling polymers) to create spherical tablets with tailored release profiles. This composite approach enhances bioavailability and gastrointestinal permeability while maintaining manufacturing feasibility.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If simple solid dosage forms are used, then ease of administration is improved, but targeting effectiveness and alignment with endogenous rhythms deteriorate

Engineering Contradiction:

Improveease of administrationVSAvoidtargeting effectiveness

Core Design Contradiction:

Ease of operationVSAdaptability or versatility

Solution Approach 1:

By segmenting the dosage into multiple spherical tablets with different release profiles (immediate and extended release) within a single capsule, the invention maintains ease of administration (one capsule taken orally) while achieving sophisticated targeting effectiveness that aligns with endogenous metabolic and physiological rhythms through controlled release patterns.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention implements periodic action through extended release mechanisms that deliver nutraceuticals over extended durations, creating release patterns that can synchronize with endogenous circadian rhythms and metabolic cycles, thereby improving targeting effectiveness without compromising ease of administration.

Inventive Principle:

Principle #19Periodic action

3Duration of action of moving object

If extended release tablets with rate controlling polymers are used, then delivery duration is extended, but device complexity increases

Engineering Contradiction:

Improvedelivery durationVSAvoidformulation complexity

Core Design Contradiction:

Duration of action of moving objectVSDevice complexity

Solution Approach 1:

The invention segments the extended release functionality into separate spherical tablets with specific rate-controlling polymer formulations, allowing each tablet to be independently optimized for specific duration profiles. This segmentation manages formulation complexity by breaking down the complex extended release requirement into manageable, standardized spherical tablet units.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The invention uses parameter changes by varying the composition and amount of rate-controlling polymers (such as hydrophilic matrices and hydrophobic coatings) in the spherical tablets to achieve different extended release durations. This approach manages formulation complexity through systematic parameter optimization rather than fundamentally complex structural designs.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances bioavailability and gastrointestinal permeability, aligning delivery with endogenous rhythms to improve health benefits.

Implementation Method 1

the matrix and the coating of the extended release tablet each comprise a rate controlling polymer in an amount sufficient to release the dose over an extended duration of time

Methodology Applied

Scientific EffectDiffusion: Diffusion

Data Source

PatentUS20250295598A1Multicomponent capsules

Publication Date: 2025.09.25 NATALS INC

AI summary

The present disclosure provides a solid dosage form for customized release of a nutraceutical, wherein the solid dosage form comprises a plurality of tablets in a single capsule, wherein at least one tablet of the plurality comprises a dose of the nutraceutical. Also provided herein are methods for improving bioavailability of a nutraceutical in a subject by administering a solid dosage form described herein.