Multi-Electrode Transcutaneous Stimulation with 3D Model Optimization
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing transcutaneous spinal cord stimulation (tSCS) technologies face challenges in achieving focal and precise stimulation due to non-focal current flows, limited ability to target multiple sites simultaneously, and difficulties in modulating neuronal circuits precisely.
Innovation Solution
A system and method that utilize a 3D model generated from CT/MRI images, combined with an optimization algorithm, to enable precise stimulation of any target location on the spinal cord with any orientation, while also allowing for simultaneous stimulation of multiple targets and avoidance of sensitive regions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional tSCS uses one or two large electrodes for stimulation, then the stimulation is noninvasive and easy to operate, but the current flow is non-focal and the activated area is large making it difficult to understand the underlying mechanism
Solution Approach 1:
The patent divides the stimulation into multiple independent channels with multiple electrodes arranged in a matrix pattern. Each electrode can be independently controlled to create focused current flows at specific locations along the spinal cord, transforming the single large electrode approach into multiple segmented stimulation sites.
Solution Approach 2:
The patent introduces a third dimension by arranging electrodes in a two-dimensional matrix array along the spinal cord length. This spatial arrangement enables current flow to be focused not only in the transverse direction but also controlled along the longitudinal axis, achieving three-dimensional current distribution control.
2Productivity
If conventional tSCS uses two-electrode montage, then the setup is simple, but it cannot target multiple sites simultaneously which limits its effectiveness
Solution Approach 1:
The stimulation system is segmented into multiple independent channels, each capable of delivering stimulation to different locations along the spinal cord simultaneously. This allows parallel processing of multiple stimulation tasks without increasing operational complexity.
Solution Approach 2:
The multi-electrode array system serves multiple functions: it can stimulate single or multiple sites, adjust stimulation intensity at each site independently, and adapt to different clinical needs. The same hardware platform provides versatile stimulation capabilities for various therapeutic applications.
3Measurement precision
If multiple electrode arrays are used to enable multisite stimulation, then more effective stepping movements and higher amplitude of EMG activity are induced, but the induced current is still not focused and sensitive regions such as the bladder cannot be avoided
Solution Approach 1:
The patent implements local quality control by independently adjusting the stimulation intensity and parameters for each electrode or electrode group. This allows different regions of the spinal cord to receive different stimulation intensities, enabling precise targeting of specific segments while avoiding sensitive areas such as the bladder through selective electrode activation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system achieves better results than conventional methods in terms of directional intensity and focality, allowing for high precision in stimulating neural networks and can be extended to other internal organs, including the brain.
Implementation Method 1
generating a 3D model of a treatment region as a function of a CT/MRI image of the treatment region
Implementation Method 2
transcutaneous spinal cord stimulation (tSCS) was used to achieve similar effects as eSCS in a noninvasive way
Data Source
AI summary
Methods, apparatus, and systems are disclosed for optimization techniques and a realistic 3D model to design optimal parameters for transcutaneous stimulation to achieve focalized stimulation of a target tissue such as the spinal cord, brain or other internal organ. The methods, apparatus, and systems include generation of a 3D model from a CT/MRI image, as well as an optimization algorithm that enables stimulation of any target location (e.g., on the dorsal root, or on the dorsal column) with any orientation at high precision.