Multilayer Endoprosthesis Structure for Vessel Wall Conformity
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Solution Overview
Problem
Existing luminal endoprostheses are rigid and fail to effectively adhere to curved or compliant blood vessel walls, leading to poor adherence and potential early implant failure, while also occluding collateral vessels and not fully restoring laminar flow or vessel function.
Innovation Solution
A multilayer luminal endoprosthesis with separated layers, featuring a threadlike element armor that mimics the structure of native blood vessel walls, allowing for flexibility and adherence during physiological deformations, and maintaining patency of collateral vessels by preventing endothelial cell growth between layers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Strength
If a rigid multilayer endoprosthesis structure is used to provide structural support and strength, then the device can maintain its shape and provide anchoring, but it fails to adhere effectively to curved or compliant blood vessel walls, leading to poor adherence and potential early implant failure
Solution Approach 1:
The endoprosthesis is divided into multiple independent layers (first layer with first threadlike element, second layer with second threadlike element) that can move relative to each other. This segmentation allows each layer to independently conform to the vessel wall while maintaining overall structural integrity, resolving the contradiction between rigidity for support and flexibility for adherence.
Solution Approach 2:
The patent introduces dynamic characteristics by allowing relative movement between the rigid layers through a clearance. This dynamic structure enables the endoprosthesis to adapt to physiological deformations and curved vessel geometries while maintaining structural support, preventing early implant failure due to poor adherence.
2Stability of the object's composition
If layers are connected together to form a unified structure, then structural integrity is improved, but flexibility and ability to adhere to curved vessel walls deteriorates
Solution Approach 1:
The endoprosthesis structure is segmented into multiple layers with a clearance between them, allowing each layer to move independently. This segmentation maintains structural integrity through the layered configuration while providing the flexibility needed to adhere to curved or compliant blood vessel walls during physiological deformations.
Solution Approach 2:
The patent employs thin filamentous layers that can flex and conform to the vessel wall geometry. These flexible thin film structures allow the endoprosthesis to adapt to curved vessels while maintaining overall structural integrity through their layered arrangement.
3Object-affected harmful factors
If a solid continuous structure is used to exclude the aneurysm, then flow diversion is achieved, but collateral vessels may be occluded and laminar flow not fully restored
Solution Approach 1:
The endoprosthesis utilizes a porous or mesh-like structure formed by interlaced threadlike elements rather than a solid continuous barrier. This porous configuration allows blood flow through collateral vessels while still achieving flow diversion from the aneurysm, preventing collateral vessel occlusion and promoting laminar flow restoration.
Solution Approach 2:
The multilayer structure with clearances mimics the natural layered architecture of blood vessel walls, creating a physiological flow pattern that restores laminar flow while excluding the aneurysm. This copying of natural structure prevents pathological flow patterns that would occlude collateral vessels.
4Volume of moving object
If layers are placed close together to form a compact structure, then device size is reduced, but flexibility and adherence to vessel walls during physiological deformations deteriorates
Solution Approach 1:
The patent incorporates a dynamic clearance between layers that allows relative movement during physiological deformations. This dynamic space enables the compact multilayer structure to expand and conform to vessel wall movements, maintaining adherence flexibility despite the compact overall device size.
Solution Approach 2:
By segmenting the structure into separate layers with clearances, the patent achieves a compact overall device size while allowing each layer to move independently for adherence. The segmented architecture provides flexibility within the compact form factor.
Data Source
AI summary
A luminal endoprosthesis assembly (1) at least partially delimits a prosthesis lumen (2), for implantation in an anatomical structure (3) that at least partially defines at least one cavity (4) and includes at least one pathological portion (13). The luminal endoprosthesis (1) has two or more layers (5, 6, 7). At least one layer (5, 6, 7) includes a threadlike element (8) forming an armor (9). The luminal endoprosthesis (1) includes an anchoring portion (10) for anchoring to an anatomical portion (11) of the walls of the cavity (4) of the anatomical structure (3), and a working portion (12) for facing the pathological portion (13) of the anatomical structure (3). The two or more layers (5, 6, 7) are separated from each other in the working portion (12) of the luminal endoprosthesis (1), avoiding connecting elements between one layer (5, 6, 7) and at least one adjacent layer.