Multi-Layered Biosensor Chip for Simultaneous Biomarker Detection
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Solution Overview
Problem
Existing ELISA technology for biomarker analysis in saliva requires expensive equipment, long analysis times, and skilled labor, limiting its practicality for non-invasive health monitoring.
Innovation Solution
A fluidic channel-based biosensor chip with a multi-layer structure and optical splitter device for simultaneous detection of multiple biomarkers, using a light-emitting and light-receiving system to enhance sensitivity and reliability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If ELISA technology is used for biomarker analysis, then measurement precision is improved, but device complexity and analysis time increase
Solution Approach 1:
The biosensor chip is divided into multiple fluidic channels, each capable of detecting different biomarkers simultaneously. This segmentation allows parallel processing of multiple detection tasks, reducing overall analysis time while maintaining precision through dedicated detection pathways for each biomarker.
Solution Approach 2:
The biosensor chip is designed as a multi-functional platform that can detect multiple types of biomarkers (e.g., cortisol, alpha-amylase, immunoglobulin A, serum amyloid A, C-reactive protein, haptoglobin) within a single integrated device. This universality eliminates the need for separate ELISA kits and equipment for each biomarker, thereby reducing device complexity while maintaining measurement precision.
2Measurement precision
If ELISA technology is used for biomarker analysis, then measurement precision is improved, but analysis time increases
Solution Approach 1:
The biosensor chip is divided into multiple fluidic channels, each capable of detecting different biomarkers simultaneously. This segmentation allows parallel processing of multiple detection tasks, reducing overall analysis time while maintaining precision through dedicated detection pathways for each biomarker.
Solution Approach 2:
The biosensor chip enables continuous detection of multiple biomarkers in parallel within the same sample volume. By maintaining continuous flow through multiple fluidic channels and performing simultaneous detection operations, the system achieves both rapid analysis and high precision without requiring sequential processing steps.
3Measurement precision
If ELISA technology is used for biomarker analysis, then measurement precision is improved, but cost increases
Solution Approach 1:
The biosensor chip is designed as a multi-functional platform that can detect multiple types of biomarkers (e.g., cortisol, alpha-amylase, immunoglobulin A, serum amyloid A, C-reactive protein, haptoglobin) within a single integrated device. This universality eliminates the need for separate ELISA kits and equipment for each biomarker, thereby reducing device complexity while maintaining measurement precision.
Solution Approach 2:
Multiple ELISA detection functions are merged into a single integrated biosensor chip with shared optical detection systems and fluidic handling. By combining multiple detection pathways into one device, the system reduces overall cost through economies of scale while maintaining the precision of individual biomarker detection through dedicated detection zones.
4Productivity
If multiple biomarkers are detected simultaneously, then productivity is improved, but device complexity increases
Solution Approach 1:
The biosensor chip is divided into multiple fluidic channels, each capable of detecting different biomarkers simultaneously. This segmentation allows parallel processing of multiple detection tasks, reducing overall analysis time while maintaining precision through dedicated detection pathways for each biomarker.
Solution Approach 2:
Multiple detection functions are nested within a compact integrated chip structure. The fluidic channels, capture antibodies, detection antibodies, and optical detection systems are all nested within a single thin-film biosensor chip, allowing high-throughput detection of multiple biomarkers without proportionally increasing external device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid, cost-effective, and reliable detection of multiple biomarkers with high sensitivity, suitable for point-of-care applications and animal health monitoring.
Implementation Method 1
measured by a light-emitting element (optical source) and a light-receiving element
Implementation Method 2
enzyme-linked immunosorbent assay (ELISA) technology, which uses an antigen-antibody specific reaction
Data Source
AI summary
The present invention relates to a biosensor technique in which multiple types of target substances (biomarkers) contained in saliva or the like are allowed to be simultaneously measured or N samples for one target substance (biomarker) are allowed to be simultaneously measured and reliability of sensed results and high sensitivity are secured. A fluidic channel-based planar biosensor chip, in which a plurality of fluidic channels capable of measuring target substances (biomarkers) are embedded in one flat plate sensor chip and the flat plate sensor chip is measured by a light-emitting element (optical source) and a light-receiving element, and a biomarker measuring apparatus using the same are provided.