Multi-Layered Dextrose Tablets for Fragility and Sensorial Issues
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Solution Overview
Problem
Multi-layered chewable tablets with high active ingredient loads face challenges in manufacturing, storage, and transportation due to fragility, and they often have adverse sensorial properties such as bitterness and poor mouthfeel, which affect the delivery and convenience of the active ingredients.
Innovation Solution
A chewable multi-layered tablet composition comprising dextrose in 50-95% weight and active ingredients in 0.1-50% weight, with at least two compressed layers, where the first layer is pre-compressed and the second layer is applied with varying pressure to create a coherent structure, enhancing saliva generation and sensorial properties.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If high load of active ingredients is incorporated in oral tablets, then the delivery effectiveness is improved, but the tablets become fragile and cause processing problems during manufacturing, storage and transportation
Solution Approach 1:
The tablet is divided into multiple layers, with the active ingredient concentrated in a specific core layer while other layers provide structural support and protective functions. This segmentation allows high active ingredient load in the core layer without compromising the overall tablet strength, as the supporting layers bear the mechanical stress during manufacturing, storage and transportation.
2Strength
If high pressure is applied for the second layer in multi-layered tablets, then a robust and cohered structure is achieved, but the friability increases and manufacturing becomes more difficult
Solution Approach 1:
The first layer is pre-compressed to achieve optimal density and mechanical strength before applying the second layer. This preliminary action creates a stable base that reduces the pressure needed for the second layer, thereby maintaining tablet coherence while reducing manufacturing complexity and avoiding excessive friability.
3Quantity of substance
If high amount of active ingredients is used relative to other ingredients, then the delivery efficacy is improved, but the sensorial properties deteriorate with pronounced bitterness and poor mouthfeel
Solution Approach 1:
Different layers of the tablet are assigned different compositions and functions: the core layer contains high concentration of active ingredients for effective delivery, while outer layers contain excipients optimized for sensorial properties such as taste masking, mouthfeel, and saliva generation. This local quality differentiation allows high active ingredient concentration without compromising overall sensorial acceptance.
4Quantity of substance
If multi-layered tablet structure is used to accommodate high active ingredient load, then the delivery capacity is improved, but the sensorial properties including mouthfeel and flavor perception deteriorate
Solution Approach 1:
The tablet employs a composite multi-layer structure where each layer is formulated with specific materials optimized for its function: the core layer uses materials compatible with high active ingredient load, while outer layers use excipients specifically selected to enhance sensorial properties including mouthfeel, flavor perception, and saliva generation. This composite approach allows simultaneous achievement of high delivery capacity and improved sensorial characteristics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The tablet formulation achieves a strong and sustained saliva generation, improved mouthfeel, and rapid release of active ingredients, addressing the issues of fragility and sensorial properties, leading to enhanced delivery and convenience.
Implementation Method 1
the compression process gives some limitations on the amount of actives to be incorporated in the layers of the tablets
Data Source
AI summary
An oral chewable tablet contains dextrose in an amount from 50 to 95% by weight of the tablet; and one or more active ingredients in an amount from 0.1 to 50% by weight of the tablet. The oral chewable tablet includes at least two compressed layers containing the dextrose and the one or more active ingredients, the first of the compressed layers being cohered to and adjacent to the second layer.