Multilayered Ingestible Tablets with Custom Dissolving Patterns
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Solution Overview
Problem
Ingestible circuits contained in tablets face variability in dissolution rates due to individual differences in physiology and environment, affecting the timing of data collection and drug delivery.
Innovation Solution
Multilayered tablets with dissolvable materials and circuits, where each layer is designed to dissolve at a specific rate, allowing for customizable and timed exposure of circuits to gather data, and potentially deliver medications based on determined dissolving patterns.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If a single-layer tablet design is used, then the device complexity is low, but the precision of timing for data collection and drug delivery cannot be customized
Solution Approach 1:
The tablet is divided into multiple layers with different dissolvable materials, each layer containing or exposing circuits at different stages. This segmentation allows precise control over when circuits are exposed and become active, enabling customized timing for data collection and drug delivery without requiring complex external control systems.
Solution Approach 2:
The tablet layers are pre-configured with specific dissolvable materials that dissolve at predetermined rates. This preliminary preparation of dissolution characteristics allows the system to automatically execute timed circuit exposure and drug delivery sequences without real-time control, achieving precise timing through pre-engineered material properties.
2Adaptability or versatility
If dissolvable materials with fixed dissolution rates are used, then the ease of manufacture is high, but the adaptability to individual physiological differences is poor
Solution Approach 1:
Different regions or layers of the tablet use different dissolvable materials with tailored dissolution rates. This local differentiation allows the system to adapt to individual physiological variations by selecting appropriate material combinations for each layer, while maintaining standardized manufacturing processes for each material type.
Solution Approach 2:
The tablet employs composite structures combining multiple dissolvable materials (e.g., starch-based, cellulose-based, gelatin-based materials) with distinct dissolution characteristics. These composite materials enable customized dissolution profiles that can adapt to individual physiological differences, while each material component can be manufactured using established techniques.
3Measurement precision
If layers with different dissolution rates are implemented, then the precision of data collection timing is improved, but the device complexity increases
Solution Approach 1:
The monitoring function is segmented across multiple layers, with each layer exposing specific circuits at different dissolution stages. This segmentation enables precise temporal separation of different physiological parameter measurements, allowing the system to collect data at optimized intervals without requiring complex timing control electronics.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables personalized and precise monitoring of physiological parameters and medication delivery by customizing tablet composition and layering to match individual dissolving patterns, improving the accuracy and timing of data collection and drug release.
Implementation Method 1
The tablet includes layers of a first and a second dissolvable material... determining dissolving times for the dissolvable materials based on the signals
Data Source
AI summary
A tablet, method of forming the tablet, and article of manufacture that includes the tablet. The tablet can include a layer of a first dissolvable material and a first circuit positioned on the layer of the first dissolvable material. The tablet can also include a layer of a second dissolvable material coating the first circuit, and a second circuit positioned on the layer of the second dissolvable material. The method can include providing the tablet, and determining a dissolving pattern for the tablet.