Multimodal His Bundle Stimulation for Brugada Conduction Correction

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Solution Overview

Problem

Conventional treatments for Brugada syndrome focus on preventing or alleviating ventricular tachycardia and fibrillation, rather than addressing the underlying conduction and activation problems, and require significant interventions that are impractical for the large population affected.

Innovation Solution

A system using implantable cardiac rhythm management devices with pacing electrodes positioned near the His bundle or para-Hisian region to deliver electrical stimulation coincident with the activation wave front from the atrioventricular node, employing either same-polarity or superimposed opposite-polarity waveforms to correct Brugada syndrome manifestations, utilizing commercially available devices.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If implantable cardioverter-defibrillator (ICD) devices are used to prevent ventricular fibrillation, then patient survival is improved, but device complexity and invasiveness increase significantly

Engineering Contradiction:

Improvepatient survivalVSAvoiddevice complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent extracts the essential therapeutic function (electrical stimulation to correct conduction abnormalities) from the complex ICD system, using only pacing electrodes and simple stimulation protocols rather than full defibrillator capabilities with multiple electrodes and complex algorithms

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent applies preliminary electrical stimulation to correct conduction abnormalities before they progress to life-threatening arrhythmias, preventing the need for more complex emergency interventions

Inventive Principle:

Principle #10Preliminary action

2Reliability

If surgical ablation procedures are performed to treat Brugada syndrome, then arrhythmia prevention is improved, but treatment invasiveness and complexity increase

Engineering Contradiction:

Improvearrhythmia preventionVSAvoidtreatment invasiveness

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent replaces mechanical surgical ablation procedures with electrical stimulation therapy delivered through implantable pacing electrodes, substituting a less invasive electrical approach for invasive surgical intervention

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If multiple single-phased superimposed waveforms of opposite polarity are delivered, then correction of Brugada manifestations is improved, but device requirements and complexity increase

Engineering Contradiction:

Improvecorrection effectivenessVSAvoiddevice requirements

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent changes the waveform parameters (polarity, phase, amplitude) to achieve effective correction using simpler single-phased waveforms of the same polarity, eliminating the need for complex multi-phased opposite-polarity waveforms while maintaining therapeutic effectiveness

Inventive Principle:

Principle #35Parameter changes

4Object-affected harmful factors

If conventional treatments focus on preventing ventricular tachycardia and fibrillation, then immediate life-threatening events are reduced, but underlying conduction problems remain unaddressed

Engineering Contradiction:

Improveventricular tachycardia and fibrillationVSAvoidunderlying conduction problems

Core Design Contradiction:

Object-affected harmful factorsVSReliability

Solution Approach 1:

The patent performs preliminary correction of underlying conduction abnormalities through electrical stimulation, addressing the root cause before it can manifest as life-threatening arrhythmias

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent converts the harmful conduction abnormalities into a treatable condition by using electrical stimulation to normalize conduction patterns, transforming the underlying pathology into a correctable electrical disturbance

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system effectively normalizes the electrocardiographic pattern and corrects conduction abnormalities associated with Brugada syndrome, reducing the risk of sudden cardiac death by proactively treating the root cause.

Implementation Method 1

deliver electrical stimulation coincident with the activation wave front from the atrioventricular node

Methodology Applied

Scientific EffectElectrical stimulation: Conduction (electrical)

Data Source

PatentUS12397164B2System for multimodal brugada syndrome treatment via electrical stimulation

Publication Date: 2025.08.26 NEWSTIM INC

AI summary

Brugada syndrome and related forms of ion channelopathies, including ventricular asynchrony of contraction, originate in the region near the His bundle or para-Hisian regions of the heart. Manifestations of Brugada syndrome can be corrected by delivering endocardial electrical stimulation coincident to the activation wave front propagated from the atrioventricular (AV) node early enough to compensate for the conduction problems that start in those regions. The stimulation can be delivered in multiple modes and can include waveforms of the same polarity delivered to a site within the region near the His bundle or para-Hisian regions of the heart associated with a low cardiac electrical asynchrony level or can include at least two single-phased superimposed waveforms of opposite polarity delivered through a pair of pacing electrodes relative to a reference electrode, which can be delivered to any site within the region near the His bundle or para-Hisian regions.