Multi-Modal Imaging Platform With Translating Stage Switching
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Solution Overview
Problem
Current imaging systems lack the capability to efficiently switch between multiple imaging modalities on the same platform, limiting their ability to provide comprehensive and optimized quantitative measurements of samples using different imaging techniques such as optical, fluorescence, and chemiluminescence imaging.
Innovation Solution
A multi-feature imaging system is developed that includes a base plate with exposed regions, a sample stage, and translation mechanisms to position the sample and illumination devices, allowing for controllable switching between line-scanning and area imaging modalities, enabling simultaneous or sequential imaging using different modalities like fluorescence and chemiluminescence imaging systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple imaging modalities are integrated on the same platform, then imaging versatility is improved, but device complexity increases
Solution Approach 1:
The base plate is divided into multiple exposed regions (first exposed region, second exposed region) that can independently accommodate different imaging modalities. Each region can be independently accessed by translating the sample stage to different positions, allowing separate optimization of each imaging modality while maintaining overall system integration.
Solution Approach 2:
A single imaging platform is designed to support multiple imaging modalities (optical imaging, fluorescence imaging, chemiluminescence imaging) on the same base plate. The sample stage can be translated to position samples under different imaging regions, enabling one system to perform multiple imaging functions that would traditionally require separate devices.
2Productivity
If automated switching between imaging modalities is implemented, then productivity is improved, but device complexity increases
Solution Approach 1:
The sample stage is made dynamically movable along the first axis between different positions (first position, second position) to access different imaging regions. This dynamic repositioning capability allows automated switching between imaging modalities by translating the sample to the appropriate position under each imaging modality, enabling high-throughput multi-modal imaging without requiring complex optical switching mechanisms.
Solution Approach 2:
The translation mechanism acts as an intermediary that moves the sample between different imaging regions rather than moving the imaging systems themselves. This approach simplifies the control architecture by using a single degree-of-freedom translation stage to switch between modalities, avoiding the need for multiple independent positioning systems or complex optical path switching mechanisms.
3Measurement precision
If quantitative measurements are optimized across multiple modalities, then measurement precision is improved, but device complexity increases
Solution Approach 1:
Different exposed regions on the base plate are dedicated to specific imaging modalities optimized for their respective measurement requirements. The first exposed region can be optimized for optical imaging with appropriate illumination and detection, while the second exposed region can be optimized for fluorescence or chemiluminescence imaging. This segmentation allows each modality to achieve optimal measurement precision without compromising other modalities.
Solution Approach 2:
Each imaging region on the base plate is configured with local optimizations tailored to its specific imaging modality. This includes positioning illumination devices, detectors, and optical components to achieve the best possible measurement precision for each specific imaging type at its designated location, rather than using a uniform configuration for all modalities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This system enables optimized quantitative measurements and comprehensive imaging of samples by allowing automated switching between imaging modalities, enhancing the ability to capture detailed spatial and temporal information from samples using various imaging techniques on a single platform.
Implementation Method 1
an illumination device located proximal to the base plate, and configured to illuminate a portion of the first exposed region in the base plate
Implementation Method 2
a first imager located proximal to the base plate on the side opposite the sample stage and configured to image the portion of the first exposed region in the base plate
Implementation Method 3
a second imager located proximal to the base plate and configured to image a region proximal to the second exposed region in the base plate
Data Source
AI summary
Multi-modality imaging systems and methods for enabling controllable and/or automated switching between different imaging systems or modes. An imaging system includes a base plate having a first exposed region and a second region, a sample stage configured to hold a sample platform, and a first translation mechanism configured to translate the sample stage on the base plate along a first axis between a first position and a second position. In the first position the sample stage is positioned proximal to the first exposed region, and in the second position, the sample stage is positioned proximal to the second region. An illumination device is configured to illuminate a portion of the first exposed region, and a second translation mechanism is configured to translate the illumination device along a second axis substantially perpendicular to the first axis.