Multimodality ID Markers for Accurate ROI Delineation
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Solution Overview
Problem
Existing marker systems for localizing lesions in the body, particularly in breast tissue, struggle to uniquely identify multiple markers simultaneously on imaging systems, leading to suboptimal guidance during surgical procedures and potential marker migration.
Innovation Solution
Markers with unique identifiable features, including radio opaque markings, antennae shapes, and external identification elements, are implanted with a microelectronic chip storing a unique electronic ID, allowing for individual tracking and localization using multimodality imaging systems.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple markers are placed in a single anatomical region to define or bracket the extent of the lesion, then the localization accuracy is improved, but the ability to uniquely identify and distinguish each marker on imaging systems deteriorates
Solution Approach 1:
The marker system is segmented into multiple distinct components, each with unique identifying features. Each marker contains a header with modality-specific identifiers and a unique serial number, allowing individual differentiation. The markers are physically separated and independently identifiable through multiple imaging modalities (X-ray, MRI, CT, ultrasound) using their distinct radiopaque markings, electromagnetic signatures, or acoustic characteristics.
Solution Approach 2:
The identification system transitions from two-dimensional visual similarity to multi-dimensional differentiation. Markers are distinguished across multiple dimensions: spatial position, radiopaque marking patterns, electromagnetic frequency signatures, acoustic resonance characteristics, and electronic ID data. This multi-dimensional approach enables unique identification of each marker even when they occupy similar anatomical regions.
2Adaptability or versatility
If hook-wire localization devices are used to localize non-palpable lesions, then the localization capability is provided, but the procedure becomes painful and technically challenging
Solution Approach 1:
The mechanical hook-wire system is replaced with a multimodality marker system that utilizes electromagnetic fields, acoustic waves, and radiopaque imaging characteristics. The markers respond to electromagnetic signals from locators, emit acoustic signals, or provide radiopaque contrast, eliminating the need for mechanical hooks and wires that cause pain and technical difficulty during insertion and localization.
Solution Approach 2:
An intermediary locator system is introduced between the surgeon and the target lesion. The locator device emits electromagnetic or acoustic signals that interact with the markers, providing real-time feedback on marker position and orientation. This intermediary system simplifies the localization process compared to direct mechanical wire manipulation, reducing technical difficulty and patient discomfort.
3Ease of operation
If markers are placed into or close to the ROI to mark the position, then the guidance for surgical procedures is provided, but marker migration may occur over time
Solution Approach 1:
Multiple stabilization mechanisms are merged into a single integrated marker system. The markers incorporate radiopaque materials for imaging visibility, electromagnetic components for signal response, and acoustic elements for detection. This combined approach provides redundant stabilization and identification methods, ensuring markers remain in position while maintaining surgical guidance capability.
Solution Approach 2:
The marker system incorporates feedback mechanisms through multimodality detection. Imaging systems can track marker position changes over time, and electromagnetic or acoustic sensors can detect marker movement. This feedback enables real-time monitoring of marker stability and allows for corrective action if migration occurs, maintaining reliable surgical guidance.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate delineation and removal of surgical regions of interest by visually and electronically distinguishing each marker, enhancing surgical precision and reducing marker migration.
Implementation Method 1
The marker can have a microelectronic chip, for example an RFID chip. The VID of each marker can be established by at least one feature from a group of features including for example; radio opaque markings
Data Source
AI summary
Multimodality markers for delineation of a region of interest (ROI) within a patient's body are disclosed. The markers may comprise a hermetic bio-compatible container and an external element that is associated with the hermetic bio-compatible container. A unique collective identification (ID) is assigned to each of the markers. The collective ID can comprise a visible component seen on an imaging system and an electronic component stored in a microelectronic chip and embedded within the hermetic bio-compatible container.