Multimolecular Composition for Intestinal Permeability Restoration
Solution Overview
Problem
Current treatments for degenerative diseases such as Parkinson's and Alzheimer's do not effectively address intestinal hyperpermeability, a key factor contributing to these multifactorial diseases.
Innovation Solution
A composition comprising specific molecules like oleic acid, palmitic acid, Lauric acid, Azélaic acid, Farnesyl cysteine, cholesterol, and others, which work together to reduce inflammation, restore intestinal permeability, and combat bacterial, viral, and fungal infections.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments targeting single factors are used for degenerative diseases, then specific symptoms can be reduced, but the diseases are never completely cured and intestinalhyperpermeability remains unaddressed
Solution Approach 1:
The composition combines multiple molecules (oleic acid, palmitic acid, lauric acid, linoleic acid, azelaic acid, farnesyl cysteine, palmitoleic acid, cholesterol, thioctic acid, myristic acid, orotic acid, acetic acid, butyric acid, lactic acid, propionic acid) that collectively address intestinal permeability, inflammation, oxidative stress, and microbial balance, enabling a single treatment to target multiple disease factors simultaneously
Solution Approach 2:
The patent employs a composite formulation integrating diverse molecular components with complementary functions - fatty acids for membrane integrity and anti-inflammation, antioxidants for oxidative stress, and antimicrobial agents for dysbiosis - creating a synergistic therapeutic system that addresses the multifactorial nature of degenerative diseases
2Reliability
If probiotics and prebiotics are administered to prevent or combat dysbiosis, then some effectiveness is achieved, but the effectiveness is very variable and depends on the patient's basic intestinal flora
Solution Approach 1:
The composition includes specific concentrations of fatty acids (oleic, palmitic, lauric, linoleic, azelaic, palmitoleic, myristic) and other molecules that can modify the intestinal environment parameters - pH, oxygen levels, nutrient availability - thereby creating conditions favorable for beneficial flora while抑制ing pathogenic bacteria, regardless of the patient's baseline flora composition
Solution Approach 2:
The fatty acids and other molecules in the composition act as intermediaries that mediate between the administered treatment and the patient's intestinal flora, modifying the intestinal environment to support beneficial bacteria while reducing dependence on the specific characteristics of the patient's baseline flora
Data Source
Figure 1a~2a
Figure 2b~3
Figure 4~5
AI summary
The present invention relates to a composition comprising at least the following molecules: oleic acid, palmitic acid, lauric acid, linoleic acid, azelaic acid, farnesylcysteine, palmitoleic acid, cholesterol, thioctic acid, myristic acid, orotic acid, acetic acid, butyric acid, lactic acid, propionic acid, and/or a salt and/or an ester and/or an anhydride of one or more of these molecules, and use thereof in particular as medicine.