Multi-Phase Nicotine Composition for Osmotic Release Control

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Solution Overview

Problem

Existing nicotine delivery methods lack effective means for controlled release and variety of delivery options, particularly for nicotine replacement therapy.

Innovation Solution

Compositions comprising a hydrophilic internal phase suspended within a hydrophobic external phase, utilizing osmotic pressure differentials for controlled release, with applications in oral strips, spray delivery systems, smokeless tobacco products, and aerosol delivery devices.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional nicotine delivery methods are used, then nicotine can be delivered to users, but the release mechanism is uncontrolled and unstable leading to inconsistent absorption

Engineering Contradiction:

Improverelease stabilityVSAvoidabsorption consistency

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent utilizes osmotic pressure differentials as a key parameter to drive controlled release. By creating a hydrophilic internal phase suspended in a hydrophobic external lipid phase, the system establishes an osmotic gradient that controls the rate at which nicotine is released from the suspension, ensuring consistent absorption over time.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention employs a composite suspension structure consisting of an internal hydrophilic phase containing nicotine and other materials, suspended within an external hydrophobic lipid phase. This composite structure enables controlled release by maintaining distinct phases that interact through osmotic pressure, providing both stability and consistent delivery.

Inventive Principle:

Principle #40Composite materials

2Ease of manufacture

If nicotine is delivered using simple formulations, then the product is easy to manufacture, but the delivery is inconsistent and lacks controlled release

Engineering Contradiction:

Improveproduct simplicityVSAvoidrelease control

Core Design Contradiction:

Ease of manufactureVSManufacturing precision

Solution Approach 1:

The nicotine delivery system is segmented into distinct phases: an internal hydrophilic phase containing the active nicotine and other materials, and an external hydrophobic lipid phase. This segmentation allows each phase to perform its specific function while maintaining overall system simplicity for manufacturing.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The hydrophobic lipid phase acts as an intermediary between the hydrophilic internal phase containing nicotine and the external environment. This intermediary layer enables controlled interaction through osmotic pressure differentials, providing precise release control without complicating the manufacturing process.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Duration of action of stationary object

If nicotine products are stored for extended periods, then distribution and usage flexibility is improved, but absorption rates become inconsistent

Engineering Contradiction:

Improvestorage durationVSAvoidabsorption rate consistency

Core Design Contradiction:

Duration of action of stationary objectVSReliability

Solution Approach 1:

The suspension structure is designed to cushion against degradation during storage by maintaining stable phase separation between the hydrophilic internal phase and hydrophobic external phase. This pre-established structure prevents premature mixing or degradation, ensuring consistent absorption rates even after extended storage periods.

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Solution Approach 2:

The invention relies on the stability of phase transitions (or lack thereof) during storage. By maintaining distinct hydrophilic and hydrophobic phases that do not spontaneously mix during storage, the system preserves its controlled release mechanism, ensuring consistent absorption rates upon use regardless of storage duration.

Inventive Principle:

Principle #36Phase transitions

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Provides controlled and varied delivery of nicotine and other materials, ensuring stability and consistent release rates over time, suitable for oral and inhalation-based nicotine replacement therapies.

Implementation Method 1

release of the internal phase material can be driven substantially by osmotic pressure differentials between the internal phase material and a surrounding environment

Methodology Applied

Scientific EffectOsmotic pressure differential: Osmotic Pressure

Data Source

PatentUS12629361B2Multi-phase delivery compositions and products incorporating such compositions

Publication Date: 2026.05.19 MODORAL BRANDS INC

AI summary

The present disclosure relates to compositions that are useful in the delivery of various materials. In particular, the compositions comprise a suspension wherein an internal phase material is surrounded by an external phase material. The internal phase specifically can be a hydrophilic material, and the external phase specifically can be a hydrophobic material. The materials are combined so that the internal phase is substantially encapsulated by the external phase such that release can be controlled in relation to osmotic pressure differentials. The suspension can be combined with a carrier, and various systems and products can be formed with the suspension and optional carrier, such as oral strips, spray delivery systems, smokeless tobacco products, aerosol delivery devices, cigarettes, and packaging.