Multiphasic Biomaterials with Hydroxylated Aromatic Moieties for Tissue Adhesion
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Solution Overview
Problem
Current biomedical constructs for tissue regeneration lack integrated, suturable designs that can incorporate therapeutic agents and provide effective adhesion to soft and hard tissues, while also controlling infiltration of unwanted agents like water and bacteria.
Innovation Solution
The development of composite biomedical materials with hydroxylated aromatic moieties, such as dihydroxybenzene (DHB), which facilitate integration of structural and therapeutic components, providing adhesion and bioactivity through various forms like salt forms, polymerized particles, and surface modifications, and incorporating a barrier layer to control infiltration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional collagen membranes are used for tissue regeneration, then biocompatibility and hemostatic properties are provided, but adhesion to soft and hard tissues is insufficient and therapeutic agents cannot be effectively incorporated
Solution Approach 1:
The patent employs composite materials by combining collagen with hydroxylated aromatic compounds (such as DHB - dihydroxybenzene). This composite approach enables the membrane to simultaneously provide biocompatibility from collagen while gaining enhanced adhesion properties and therapeutic agent incorporation capabilities from the hydroxylated aromatic moieties, which can form chemical bonds with both soft and hard tissues.
Solution Approach 2:
The patent modifies the chemical parameters of traditional collagen membranes by incorporating hydroxylated aromatic compounds. This parameter change introduces new functional groups that enable chemical adhesion to both soft and hard tissues, and provides binding sites for therapeutic agents, thereby transforming the membrane from a passive barrier to an active, multifunctional construct.
2Reliability
If biomedical constructs are designed to incorporate therapeutic agents, then therapeutic effectiveness is improved, but control over infiltration of unwanted agents like water and bacteria is compromised
Solution Approach 1:
The patent applies local quality by creating a membrane with differentiated functional zones. The hydroxylated aromatic moieties are strategically incorporated to provide localized adhesion and therapeutic binding sites, while the overall membrane structure maintains barrier functionality. This localized functional enhancement allows therapeutic agent incorporation without compromising the barrier property against harmful infiltrations.
Solution Approach 2:
The hydroxylated aromatic compounds act as intermediaries that bridge the therapeutic agents and the collagen matrix. These intermediary moieties provide specific binding sites for therapeutic agents while maintaining the structural integrity and barrier function of the collagen membrane, thus mediating between therapeutic delivery and protective barrier functions.
3Adaptability or versatility
If integrated multiphasic constructs are developed for multi-tissue regeneration, then versatility and adhesion capabilities are enhanced, but device complexity and manufacturing difficulty increase
Solution Approach 1:
The patent applies preliminary action by pre-incorporating hydroxylated aromatic compounds into the collagen matrix during the manufacturing process. This preliminary incorporation of functional moieties simplifies subsequent steps, as the membrane is already equipped with adhesion and therapeutic binding capabilities before implantation, reducing the need for complex post-manufacturing modifications or multiple separate components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
These materials enhance bioactivity, bioadhesion, and tissue regeneration capabilities, offering improved handling and bioactivity for applications in bone, periodontal ligament, and other tissue regeneration processes, while maintaining effectiveness in wet environments.
Implementation Method 1
provide bioadhesion of the biomedical material to soft/hard tissues
Implementation Method 2
provide free hydroxyls that can cross-link the components of the composite materials
Implementation Method 3
acts as a barrier layer to prohibit or control infiltration of unwanted agents
Data Source
AI summary
Disclosed herein are composite materials which may be used as biomedical materials or constructs. The disclosed biomedical materials or constructs may be multiphasic and typically provide a surface for cell growth. The disclosed biomedical materials and constructs typically comprise conjugable and/or adhesive chemical moieties, such as hydroxylated aromatic moieties, which facilitate integration of the components of the biomedical materials and constructs. Suitable hydroxylated aromatic moieties may include dihydroxybenzene (DHB) moieties, such as 1,2-DHB moeities, and derivatives thereof.