Correlated Multiphasic Analysis for Low-Threshold DNA Match Correlation

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Solution Overview

Problem

Conventional methods for autosomal DNA analysis are limited in identifying ancestral connections beyond the top 5% of matches, struggling with missing or inaccurate family trees, non-paternity events, and low shared DNA thresholds, leaving 95% of matches unidentified.

Innovation Solution

Correlated Multiphasic Analysis (CMA) evaluates associative properties across multiple DNA matches, grouping them into functional equivalence classes based on verified Most Recent Common Ancestor relationships, providing insights beyond traditional segmental analysis and supporting interactive queries without requiring advanced scientific knowledge.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If conventional segmental analysis methods are used to identify ancestral connections, then analysis simplicity is maintained, but the number of identifiable matches is limited to only the top 5% of matches within a 200-year window

Engineering Contradiction:
Improvenumber of identifiable matchesVSAvoidanalysis complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent segments the analysis process into multiple phases: (1) gathering atDNA matches and family tree data, (2) identifying verified MRCA relationships, (3) clustering matches into functional equivalence classes based on shared MRCAs, and (4) iteratively expanding the analysis. This segmentation allows the system to handle complexity systematically while dramatically increasing the number of identifiable matches from 5% to potentially 95%+ of all matches.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The patent adds a new dimension to traditional DNA analysis by introducing functional equivalence classes that group matches based on shared MRCAs rather than just DNA segment length. This creates a hierarchical structure where matches are organized by ancestral relationships across multiple generations, enabling the analysis to extend beyond the traditional 200-year window and identify distant relationships that conventional methods miss.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

2Quantity of substance

If traditional DNA analysis methods are used, then data processing requirements remain low, but 95% of matches remain unidentified due to missing or inaccurate family trees and low shared DNA thresholds

Engineering Contradiction:
Improvenumber of identifiable matchesVSAvoidunidentified matches
Core Design Contradiction:
Quantity of substanceVSLoss of information

Solution Approach 1:

The patent performs preliminary actions by gathering and organizing family tree data and atDNA match data before the actual analysis. It pre-identifies verified MRCA relationships and uses these as anchor points to build functional equivalence classes. This preliminary organization of data allows the system to effectively analyze matches even when family trees are incomplete, as the verified MRCAs provide reliable starting points for clustering.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The patent introduces functional equivalence classes as an intermediary structure that connects atDNA matches to ancestral relationships. Instead of directly linking matches to specific ancestors (which requires complete family trees), the system uses MRCAs as intermediaries to group matches into classes. This intermediary approach allows matches with low shared DNA or incomplete family tree data to still be identified through their association with the functional equivalence class.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Reliability

If conventional matching thresholds are applied (typically 40 cM), then false positives are reduced, but the number of identifiable ancestral connections is severely limited

Engineering Contradiction:
Improvematch accuracyVSAvoidnumber of identifiable matches
Core Design Contradiction:
ReliabilityVSQuantity of substance

Solution Approach 1:

The patent merges multiple matches into functional equivalence classes based on shared MRCAs. By combining evidence from multiple matches within a class, the system can identify ancestral connections even when individual matches fall below conventional 40 cM thresholds. The collective weight of multiple lower-threshold matches within a verified equivalence class provides reliable identification of distant ancestral relationships.

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The patent creates a universal framework for analyzing all atDNA matches regardless of their individual DNA segment length. The functional equivalence class approach allows the system to handle matches across the entire spectrum of DNA sharing, from close relatives with high cM values to distant relatives with low cM values, using the same MRCA-based clustering methodology. This universal approach eliminates the need to apply different analysis methods based on match strength.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Data Source

PatentUS20230077642A1Systems and methods for performing Correlated Multiphasic Analysis
Publication Date: 2023.03.16 KONANUR ARUN CHRISTOPHER
  • US20230077642A1 patent drawing
  • US20230077642A1 patent drawing
  • US20230077642A1 patent drawing

AI summary

A bioinformatic system that identifies the common ancestral origins of otherwise uncorrelated autosomal DNA (atDNA) matches is disclosed. The invention consists of three main components: The first is Correlated Multiphasic Analysis (CMA) a process of logically associating subsets of In Common With (ICW) atDNA matches in order to arrive at a solution set for queries investigating ancestral family lines. The second is a set of automated scripts, formulae, and data structures to facilitate desktop correlation and tabulation utilizing CMA in conjunction with a desktop spreadsheet program such as Microsoft Excel. The third is a system of data tables and methods to facilitate CMA within a database management system (DBMS) at the enterprise level.