Multiple Tangential Flow Filtration Stations with Unified Controller
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Solution Overview
Problem
Existing tangential flow filtration (TFF) systems face challenges in efficiently testing and optimizing process parameters such as pump flow rates, pressure conditions, and buffer types, which can lead to experimental variance and increased time in developing an optimal process.
Innovation Solution
A multiple TFF apparatus is designed with a single main controller to manage multiple TFF systems, allowing for simultaneous testing of different conditions in an automated fashion. This system includes features like adjustable level sensors, air-in-tube detectors, and throttle valves to optimize filtration processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple TFF systems are operated in series to test different process parameters, then each system can be individually optimized, but the development time increases significantly and experimental variance increases due to batch differences
Solution Approach 1:
The system is divided into multiple independent TFF stations (at least two stations) that can operate simultaneously. Each station has its own TFF system with pump, filter, and vessel, allowing parallel testing of different process parameters without sequential delays
Solution Approach 2:
A single main controller is designed to control multiple TFF systems through a unified graphical user interface. The controller can manage different filtration modes (batch, continuous, diafiltration) across multiple stations simultaneously, enabling one system to perform multiple experimental conditions in parallel
2Ease of operation
If multiple TFF systems are controlled manually or through separate controllers, then each system can be independently monitored, but the complexity of operation and data collection increases
Solution Approach 1:
The main controller is designed as a universal control system that can manage multiple TFF stations through a single graphical user interface. The controller handles pump control, filtration mode selection, and data collection for all stations simultaneously, reducing operational complexity despite managing multiple systems
Solution Approach 2:
Multiple control functions (pump control, filtration mode management, data collection, system monitoring) are merged into a single main controller. The unified graphical user interface consolidates control of all TFF stations, eliminating the need for separate control interfaces and reducing operational complexity
3Measurement precision
If process parameters are tested sequentially over longer periods, then detailed analysis can be performed on each condition, but experimental variance increases due to potential changes in product batches and environmental conditions
Solution Approach 1:
The system segments the experimental process into parallel stations, each testing different parameters simultaneously. This segmentation allows all experiments to occur under the same environmental conditions and using the same product batch, eliminating temporal variance while maintaining the ability to analyze each condition independently through the main controller
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system reduces experimental variance by enabling parallel testing of process conditions, thereby decreasing the time required to develop an optimal TFF process. It also allows for remote control and data collection, streamlining the analysis and optimization of biopharmaceutical processing.
Implementation Method 1
a pump for circulating a flow of liquid between said product vessel and said filter
Implementation Method 2
The flow of that liquid causes the constant removal of material from the inner walls of the filters that would otherwise quickly clog the filter membrane
Implementation Method 3
the tube or plate membrane wall is designed to allow for the passage of very small components, along with the fluid from the vessel
Implementation Method 4
whereby a product liquid is fed by gravity to the product vessel
Data Source
AI summary
A multiple tangential flow filtration (TFF) apparatus includes a plurality of tangential flow filtration (TFF) systems, a support frame defining a plurality of stations for supporting individual TFF systems and a single controller for controlling the plurality of tangential flow filtration systems. Each of the systems include at least a product vessel, a tangential flow filtration (TFF) filter and a pump for circulating a flow of liquid between said product vessel and said filter.