Multiplex Analytic Device Calibration With Stream-Specific Adjustments

The calibration function is segmented into two distinct parts: a common calibration function that applies to all hardware components, and individual adjustment factors specific to each component. This segmentation allows the system to capture both the general calibration relationship and the component-specific variations without requiring fully separate calibration procedures for each component.

Instead of applying a uniform calibration approach to all hardware components, the method introduces local adjustment factors that are specific to each individual component. These adjustment factors allow each component to have its own calibrated characteristics while sharing the common calibration framework, thereby improving measurement precision for each component without requiring completely separate calibration procedures.

The method enhances the simple average calibration approach by introducing component-specific adjustment factors. Each hardware component receives the common calibration function plus its own tailored adjustment, ensuring that local variations in component performance are accounted for. This maintains the low calibration burden of a single average function while eliminating the bias that would otherwise affect analytical results.

The calibration process incorporates feedback mechanisms where the individual adjustment factors are determined based on measured deviations from the common calibration function. These adjustment factors are then used to correct subsequent measurements, creating a feedback loop that continuously improves measurement precision while maintaining the simplicity of the overall calibration approach.

The calibration model is segmented into a common calibration function that can be established with a standard number of calibrator levels, and individual adjustment factors that require minimal additional calibration data. This segmentation allows the system to achieve high calibration model accuracy without requiring an excessive number of calibrator levels for each individual component.

The method merges the calibration data from multiple hardware components into a single common calibration function, while simultaneously extracting individual adjustment factors from the same or minimal additional data. This combining approach allows the system to achieve comprehensive calibration accuracy across all components without requiring separate extensive calibration procedures for each component, thereby reducing total calibration time.