Multispectral Imaging for Asymptomatic PAD Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods for detecting peripheral arterial disease (PAD) in asymptomatic patients are inadequate, as conventional ankle-brachial index (ABI) tests have limited sensitivity and are not effective in identifying patients without classic symptoms, leading to delayed diagnosis and potential progression of the disease.
Innovation Solution
A multispectral imaging system that combines multi-spectral physiologic visualization (MSPV), peripheral oxygen saturation (SpO2) measurement, and physiologic status parameter analysis to provide real-time blood flow distribution, oxygen saturation, and tissue perfusion data, allowing for early detection of PAD in asymptomatic patients.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional ankle-brachial index (ABI) test is used to detect PAD, then the test is accurate for symptomatic patients, but it has limited sensitivity and fails to detect PAD in asymptomatic patients
Solution Approach 1:
The patent combines multiple imaging modalities (laser speckle contrast imaging for blood flow, multi-spectral imaging for oxygen saturation, and ultrasound for anatomical visualization) into a single integrated system. This merging of techniques allows simultaneous assessment of perfusion, oxygenation, and anatomy, enabling detection of PAD in asymptomatic patients while maintaining accuracy for symptomatic cases
Solution Approach 2:
The imaging system is designed to perform multiple functions: visualizing blood flow distribution, measuring tissue oxygen saturation, assessing perfusion parameters, and detecting anatomical abnormalities. This multi-functionality allows the same system to effectively diagnose both symptomatic and asymptomatic PAD patients, overcoming the limitations of single-modality tests
2Ease of operation
If conventional ABI test is used, then the test procedure is simple, but it provides insufficient information for early detection in asymptomatic patients
Solution Approach 1:
The patent replaces the mechanical pressure measurement approach of conventional ABI with optical imaging techniques. Laser speckle contrast imaging and multi-spectral imaging provide non-contact, visualization-based assessment of blood flow and oxygen saturation, maintaining operational simplicity while delivering comprehensive physiologic information for early PAD detection
3Reliability
If comprehensive imaging system is implemented, then early detection capability is improved, but device complexity increases
Solution Approach 1:
The imaging system is divided into distinct functional modules: laser speckle contrast imaging module for blood flow visualization, multi-spectral imaging module for oxygen saturation measurement, and ultrasound module for anatomical assessment. Each module operates independently but contributes to the overall diagnostic capability, allowing comprehensive early detection while managing system complexity through modular design
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system enables early and accurate diagnosis of PAD in asymptomatic patients by integrating anatomical and physiologic data, reducing the risk of disease progression and improving patient outcomes by identifying PAD before severe symptoms appear.
Implementation Method 1
an illumination control module configured to image a sample and provide an imaging output sequence
Implementation Method 2
a multi-spectral physiologic visualization (MSPV) module configured to receive the imaging output sequence and provide real-time blood flow distribution visualization
Implementation Method 3
a peripheral oxygen saturation (SpO2) module configured to provide real-time SpO2 information at a tissue surface level
Data Source
AI summary
Multispectral imaging systems are provided including an illumination control module configured to image a sample and provide an imaging output sequence including images and data; a multi-spectral physiologic visualization (MSPV) module, a peripheral oxygen saturation (SpO2) module and a physiologic status parameters (PSP) module configured to receive the imaging output sequence of the illumination control module simultaneously. The MSPV module is configured to provide real-time blood flow distribution visualization of a field of view (FOV) responsive to the received imaging output sequence. The SpO2 module is configured to provide real-time SpO2 information at a tissue surface level for the FOV responsive to the received imaging and output sequence. The PSP module is configured to derive status parameters in real-time from metadata associated with the received imaging and output sequence of the FOV. The system further includes a processing engine configured to integrate and analyze the real-time blood flow distribution visualization, SpO2 information and derived status parameters.