Multi-step Skin Care Regimen for Anti-aging via Gene Expression
Solution Overview
Problem
Current cosmetic regimens for anti-aging lack scientific insight into the interaction between skin care actives and biological processes, failing to optimize the order of application for enhanced anti-aging benefits, despite the use of multiple actives in formulations.
Innovation Solution
A multi-step regimen is developed where a first formulation with actives for skin cleansing and hydration is applied followed by a second formulation with actives for skin repair and rebuilding, leveraging eigengene-derived biological pathways to enhance anti-aging effects, using bioinformatics to optimize the order of application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If multiple skin care actives are applied in a single formulation or routine regimen, then the coverage of multiple biological mechanisms is improved, but the interaction and interplay between the actives and biological processes cannot be optimized
Solution Approach 1:
The patent segments the skin care regimen into multiple distinct formulations (first formulation with cleansing/hydration actives, second formulation with repair/rebuilding actives) applied in a specific sequence. This segmentation allows each formulation to target specific biological mechanisms without interference, while the sequential application optimizes the interaction between actives and skin processes.
2Adaptability or versatility
If multiple formulations are applied in a regimen, then the ability to target different biological mechanisms is improved, but the order of application and interplay between mechanisms is not scientifically optimized
Solution Approach 1:
The patent applies preliminary action by first applying a formulation designed to prime the skin through cleansing and hydration mechanisms, creating an optimal state for subsequent application of repair and rebuilding actives. This sequential approach ensures that the skin is properly prepared before receiving the second formulation, maximizing the effectiveness of each active ingredient.
3Ease of manufacture
If actives are applied without considering biological process interplay, then the formulation process is simplified, but the anti-aging benefit is not maximized
Solution Approach 1:
The patent changes the parameter of application sequence from arbitrary or simultaneous to a specific optimized order (first formulation then second formulation). This parameter change is based on understanding the interplay between different biological processes, ensuring that cleansing and hydration occur before repair and rebuilding, thereby maximizing anti-aging benefits while maintaining formulation simplicity.
Data Source
AI summary
Multi-step cosmetic regimens are provided to improve the appearance of aging skin. A target portion of skin that exhibits a sign of skin aging is identified. A first formulation is topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a genetic co-expression module for one or more biological themes associated with skin cleansing and/or skin detoxification, and/or skin hydration to the target portion of skin. A second formulation is also topically applied, comprising at least one active possessing an ability to transcriptionally up-regulate an eigengene derived from a co-expression module for one or more biological themes associated with skin repair and/or rebuilding to the target portion of skin.