Multivalent Acid Coating for Medical Stents
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Solution Overview
Problem
Current medical devices, such as stents, face challenges in bioerosion control, anti-tumor effects, antioxidant properties, and drug elution, which are not adequately addressed by existing coatings.
Innovation Solution
The use of a metallic region coated with a multivalent acid, such as phytic acid, which slows bioerosion, provides anticancer effects, acts as an antioxidant, and facilitates drug release, combined with ceramic particles and charged therapeutic agents in a multilayer assembly process.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional coatings are used on medical devices, then the device structure is simple, but the device fails to provide adequate bioerosion control, anti-tumor effects, and antioxidant properties
Solution Approach 1:
The patent applies composite materials by combining multivalent acid polymers with ceramic particles to create a multi-functional coating system. The multivalent acid polymer matrix provides bioerosion control and antioxidant properties, while embedded ceramic particles enhance mechanical strength and surface properties, resolving the contradiction between improved reliability and increased device complexity through material composition rather than structural complexity
Solution Approach 2:
The multivalent acid polymer coating serves multiple functions simultaneously: it provides bioerosion control through controlled degradation, antioxidant protection against oxidative stress, anti-tumor effects through therapeutic agent delivery, and improved biocompatibility. This multi-functionality approach allows a single coating system to address multiple clinical requirements without proportionally increasing complexity
2Reliability
If a multivalent acid coating is applied to provide multiple therapeutic functions, then therapeutic efficacy is improved, but the manufacturing process becomes more complex
Solution Approach 1:
The patent employs preliminary action by pre-synthesizing the multivalent acid polymer with embedded therapeutic agents and ceramic particles before coating application. This pre-preparation of functional components allows for simplified coating deposition processes, as the complex multi-functional formulation is ready-made rather than requiring complex in-situ synthesis or multiple sequential coating steps during manufacturing
Solution Approach 2:
The patent utilizes parameter changes by adjusting the molecular weight, functional group composition, and crosslinking density of the multivalent acid polymer to optimize both therapeutic performance and coating processability. By tuning these chemical parameters, the formulation achieves desired therapeutic efficacy while maintaining compatibility with standard coating application methods, thus resolving the manufacturing complexity issue
3Productivity
If the coating provides rapid drug elution, then therapeutic effect is enhanced, but the coating durability and controlled release are compromised
Solution Approach 1:
The patent applies dynamics by designing the multivalent acid polymer coating with pH-responsive and enzyme-responsive degradation characteristics. The coating maintains structural integrity and controlled drug release under normal physiological conditions, but accelerates drug elution and degrades rapidly in response to specific pathological conditions (such as tumor microenvironment pH or enzymatic activity). This dynamic response capability allows the coating to provide both durability during normal function and rapid therapeutic effect when needed, resolving the contradiction between release rate and durability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multivalent acid coating enhances corrosion resistance, promotes endothelialization, reduces inflammation, and effectively delivers therapeutic agents, improving the performance and longevity of medical devices like stents.
Implementation Method 1
their ability to form ionic and/or covalent crosslinks
Implementation Method 2
their ability to form ionic and/or covalent crosslinks
Implementation Method 3
their ability to undergo progressive deprotonation with an increase in pH
Implementation Method 4
One explanation posited for the anticancer effects of phytic acid is its antioxidant properties
Implementation Method 5
facilitates drug release
Data Source
AI summary
According to an aspect of the present invention, medical devices are provided which comprise a metallic region and a coating on all or part of the metallic region that comprises a multivalent acid.