Multivitamin Composition for Gastrointestinal Motility
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Solution Overview
Problem
Current treatments for gastrointestinal motility disorders, such as gastroesophageal reflux disease, irritable bowel syndrome, and constipation, often have limited effectiveness and are associated with significant side effects, highlighting the need for a safer and more effective method to promote gastrointestinal motility.
Innovation Solution
A composition comprising a combination of B vitamins (including thiamine, riboflavin, niacin, pantothenic acid, vitamin B6, biotin, and vitamin C, potentially with additional components like folic acid, choline bitartrate, and inositol, administered to stimulate gastrointestinal motility and alleviate related symptoms.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If conventional drugs (metoclopramide, domperidone, itopride) are used to treat gastrointestinal motility disorders, then gastrointestinal motility is improved, but side effects increase
Solution Approach 1:
The patent changes the chemical composition parameters by replacing conventional dopamine receptor blocking drugs with a combination of vitamins (B1, B2, B6, B12, C, E) and amino acids (glycine, L-carnitine). This parameter change transforms the mechanism of action from receptor blockade to metabolic support and nerve function enhancement, thereby improving gastrointestinal motility while avoiding the side effects associated with conventional drugs such as lethargy, irritability, fatigue, and Parkinson-like symptoms.
2Speed
If high-dose or long-term use of metoclopramide is applied, then gastrointestinal motility is enhanced, but Parkinson's disease symptoms appear
Solution Approach 1:
The patent extracts and eliminates the dopamine receptor blocking mechanism that causes Parkinson's-like symptoms. Instead of using metoclopramide which blocks dopamine receptors, the invention uses vitamins and amino acids that support nerve function and metabolism without interfering with dopamine pathways, thereby removing the harmful effect while maintaining the beneficial motility enhancement.
3Speed
If domperidone is used to promote gastrointestinal peristalsis, then motility is improved, but menstrual disorders occur
Solution Approach 1:
The patent changes the pharmacological parameters by replacing domperidone (a peripheral dopamine receptor antagonist that releases prolactin) with a combination of vitamins and amino acids. This alternative mechanism enhances gastrointestinal peristalsis through improved nerve function and metabolic support without causing the menstrual disorders associated with prolactin release.
4Speed
If itopride is administered to enhance gastrointestinal movement, then gastric emptying is facilitated, but caution is needed in elderly patients
Solution Approach 1:
The patent employs vitamins and amino acids which are naturally occurring, metabolizable substances rather than potent pharmacological agents. These components are safer for elderly patients as they support metabolic functions and nerve health without the risks associated with itopride's dual mechanism of dopamine blockade and acetylcholinesterase inhibition. The body can naturally metabolize and eliminate these nutrients, reducing accumulation and adverse effects.
Data Source
AI summary
The present invention relates to a composition of multivitamin vitamin B-C, particularly a composition of vitamin B-C for stimulating gastrointestinal (GI) system motility. The composition is suitable for preventing and/or treating conditions or diseases associated with insufficient GI motility.