Multiwell Cervical Disease Detection Device
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current cervical cancer screening methods, such as Pap smears, have limitations including low sensitivity, high false-negative rates, and require significant infrastructure and trained personnel, making them inefficient and costly, especially in low-resource settings.
Innovation Solution
A multiwell device and method for cervical disease detection that allows simultaneous evaluation of multiple patient samples using conventional cytological stains and immunostaining with specific antibodies to improve diagnostic accuracy and throughput.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional Pap smear methods are used, then diagnostic accuracy can be improved through detailed examination, but productivity decreases due to sequential processing of single samples
Solution Approach 1:
The invention divides the screening process into multiple independent wells on a single slide, allowing parallel processing of multiple samples while maintaining the diagnostic quality of individual examinations. Each well contains a separate patient sample and can be evaluated independently, thus increasing throughput without sacrificing diagnostic accuracy.
Solution Approach 2:
The invention combines multiple patient samples on a single glass slide in separate wells, enabling simultaneous processing and evaluation of multiple samples in one diagnostic workflow. This merging approach maintains the precision of individual sample examination while dramatically increasing productivity through parallel processing.
2Measurement precision
If conventional single-sample processing is used, then diagnostic quality can be maintained through focused examination, but loss of time increases due to sequential evaluation of multiple samples
Solution Approach 1:
By segmenting multiple samples into separate wells on a single slide, the invention allows diagnosticians to examine multiple samples in parallel rather than sequentially. Each well maintains the focused examination quality of single-sample processing while reducing total screening time through simultaneous evaluation.
Solution Approach 2:
The invention enables continuous evaluation of multiple samples on a single slide without the need to repeatedly prepare and handle separate slides for each sample. This continuity eliminates idle time between sample examinations while maintaining diagnostic quality through standardized well configurations.
3Adaptability or versatility
If manual Pap smear processing is used, then flexibility can be maintained for various examination protocols, but productivity decreases due to labor-intensive sequential processing
Solution Approach 1:
The segmented well design allows each well to be processed independently according to different protocols or staining methods, maintaining flexibility for various examination approaches. Simultaneously, the parallel arrangement of multiple wells on one slide enables higher throughput compared to sequential single-sample processing.
Solution Approach 2:
The multiwell slide design serves multiple functions: it can accommodate different sample types, support various staining protocols, and enable both manual and automated processing. This universality maintains examination flexibility while increasing productivity through efficient use of a single slide format for multiple samples.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The multiwell device enhances diagnostic accuracy and reduces costs by enabling high-throughput cervical screening with improved sensitivity and specificity, suitable for both manual and automated procedures, benefiting both developed and developing countries.
Implementation Method 1
immunostaining with specific antibodies to improve diagnostic accuracy and throughput
Implementation Method 2
conventional cytological stains applied to the novel multiwell device
Data Source
AI summary
The present invention is a device for high-throughput detection, screening and disease management of cervical disease. The device is comprised of a solid support featuring multiple well-separated areas, each accommodating a patient sample, leading to simultaneous evaluation of patient samples. The device enables cytological staining, cervical Pap staining, and immunochemical staining using antibodies or combination of antibodies which are capable of binding to biomarkers that are overexpressed in cancer including in cervical carcinoma and dysplasia, as compared to normal controls. The device can be used in either manual or automated mode, and applied to any biological fluid or cell suspension from any biological specimen in view of a variety of cell biology assays, and in view of detection and screening of cervical and other diseases.