Multizone Microporous Membrane for High-Throughput Filtration

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Solution Overview

Problem

Existing filtration technologies face challenges in achieving high throughput performance without increasing manufacturing costs or complexity, particularly in multilayer membranes, and existing asymmetric membranes are prone to non-uniformity and particle accumulation at interfaces.

Innovation Solution

A multizone, unsupported microporous filtration membrane with a specific three-zone structure, comprising a symmetric or asymmetric first and second zone, and an asymmetric third zone positioned between them, is fabricated through a triple slot casting process, ensuring integral zones without distinct interfaces, using polymers like PVDF and hydrophilic polymers, and optionally hydrophilic coatings.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If multiple layers of membranes are used to improve throughput, then fluid processing capacity is improved, but manufacturing cost increases

Engineering Contradiction:
ImprovethroughputVSAvoidmanufacturing cost
Core Design Contradiction:
ProductivityVSEase of manufacture

Solution Approach 1:

The single membrane is segmented into multiple functional zones (retentive zone with smaller pores and pre-filtration zones with larger pores) rather than using multiple separate membrane layers. This segmentation within a single layer reduces manufacturing complexity and cost while maintaining high throughput performance through optimized flow distribution across zones.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

Different zones within the membrane have different pore sizes and structures optimized for specific functions: the retentive zone has smaller pores for fine filtration, while pre-filtration zones have larger pores for bulk flow and particle capture. This local quality variation allows each zone to perform its specific function efficiently, achieving high overall throughput without requiring multiple membrane layers.

Inventive Principle:
Principle #3Local quality

2Productivity

If asymmetric membrane structure is used to improve throughput, then fluid processing capacity is improved, but membrane uniformity deteriorates

Engineering Contradiction:
ImprovethroughputVSAvoidmembrane uniformity
Core Design Contradiction:
ProductivityVSManufacturing precision

Solution Approach 1:

The asymmetric membrane is segmented into distinct functional zones with clearly defined boundaries. The retentive zone and pre-filtration zones are created as separate regions within the same membrane layer, each with uniform pore structures optimized for their specific functions. This segmentation maintains manufacturing precision within each zone while achieving overall asymmetric performance for high throughput.

Inventive Principle:
Principle #1Segmentation

3Manufacturing precision

If sequential casting process is used to create multizone membrane, then zone differentiation is achieved, but interface particle accumulation occurs

Engineering Contradiction:
Improvezone differentiationVSAvoidthroughput
Core Design Contradiction:
Manufacturing precisionVSProductivity

Solution Approach 1:

An intermediary transition zone is created between the retentive zone and pre-filtration zones. This transition zone has intermediate pore sizes that gradually bridge the gap between the two distinct zones, preventing sharp interfaces where particles would accumulate. The transition zone acts as a mediator that maintains smooth particle flow while preserving zone differentiation.

Inventive Principle:
Principle #24Intermediary (Mediator)

4Productivity

If tight surface modification is used to improve throughput, then fluid processing capacity is improved, but process complexity increases

Engineering Contradiction:
ImprovethroughputVSAvoidprocess complexity
Core Design Contradiction:
ProductivityVSDevice complexity

Solution Approach 1:

The tight surface modification function is merged into the membrane formation process itself rather than being a separate post-processing step. The asymmetric structure with a dense retentive zone is created during the initial phase separation process, combining the benefits of tight surface filtration with high throughput in a single integrated manufacturing process, thereby reducing overall process complexity.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentUS20260021450A1Microfiltration membrane
Publication Date: 2026.01.22 MERCK MILLIPORE LTD
  • US20260021450A1 patent drawing
  • US20260021450A1 patent drawing
  • US20260021450A1 patent drawing

AI summary

The present application relates to a multizone, unsupported, microporous, high throughput membrane. The membrane includes a first microporous zone, a second microporous zone, and a third microporous zone, where the third microporous zone is positioned between the first and second microporous zones, with the first, second, and third microporous zones being integral with one another. Further aspects of the present application include a process for making the membrane and a filtration cartridge with the membrane of the present application.