Musa Ferment Prebiotic Composition for Akkermansia muciniphila Growth

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Solution Overview

Problem

Current methods fail to effectively promote the growth of Akkermansia muciniphila, a beneficial intestinal bacterium, which is crucial for maintaining intestinal health and preventing chronic diseases such as diabetes and cardiovascular diseases.

Innovation Solution

A prebiotic composition including a Musa ferment, obtained through fermentation of Musa fruit flesh with Streptococcus thermophilus, Saccharomyces cerevisiae, and Acetobacter aceti, combined with oligosaccharides like xylooligosaccharides and sugar alcohols like lactitol, is administered to promote the growth of Akkermansia muciniphila in the intestine.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional methods are used to promote Akkermansia muciniphila growth, then the growth promotion effect is insufficient, but developing new effective methods requires complex prebiotic composition formulation

Engineering Contradiction:

Improvegrowth promotion effectVSAvoidprebiotic composition formulation

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines multiple prebiotic components (Musa ferment, oligosaccharides, sugar alcohols) into a single prebiotic composition that synergistically promotes Akkermansia muciniphila growth. The Musa ferment serves as both a probiotic culture and prebiotic substrate, while the combination with oligosaccharides and sugar alcohols creates a comprehensive nutritional support system that significantly enhances bacterial proliferation compared to single-component approaches

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The prebiotic composition is formulated as a composite material containing multiple functional components: Musa ferment (providing active bacterial cultures and metabolic products), oligosaccharides (serving as prebiotic substrates), and sugar alcohols (providing additional carbon sources). This composite formulation creates a synergistic effect that collectively promotes Akkermansia muciniphila growth more effectively than individual components alone

Inventive Principle:

Principle #40Composite materials

2Reliability

If Akkermansia muciniphila is promoted to treat metabolic and cardiovascular diseases, then health benefits are improved, but the complexity of intervention strategies increases

Engineering Contradiction:

Improvedisease treatment effectivenessVSAvoidintervention strategy

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The prebiotic composition utilizes the natural metabolic pathways of Akkermansia muciniphila to achieve therapeutic effects. The bacteria themselves process the prebiotic components (oligosaccharides and sugar alcohols) through their inherent enzymatic systems, converting them into beneficial metabolites. This self-service mechanism eliminates the need for complex external intervention systems, as the bacteria's own metabolic capabilities are harnessed to produce therapeutic effects

Inventive Principle:

Principle #25Self-service

Solution Approach 2:

Akkermansia muciniphila acts as an intermediary between the prebiotic composition and the host's metabolic system. The bacteria receive prebiotic substrates, process them through their metabolic pathways, and produce beneficial metabolites that indirectly affect host health parameters (blood lipids, glucose metabolism, inflammation). This intermediary role simplifies the intervention strategy by using the bacteria as a natural bioconverter rather than requiring direct pharmacological intervention

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The prebiotic composition significantly increases the number of Akkermansia muciniphila, reducing body weight, fat percentage, waist circumference, and hip circumference, thereby alleviating metabolic and cardiovascular diseases.

Implementation Method 1

the Musa ferment is obtained by a first fermentation and a second fermentation of a mixture of Musa fruit flesh and water, wherein the first fermentation is carried out with Streptococcus thermophilus and Saccharomyces cerevisiae, and the second fermentation is carried out with Acetobacter aceti

Methodology Applied

Scientific EffectFermentation: Fermentation

Data Source

PatentUS11478525B2Method for promoting growth of <i>Akkermansia muciniphila </i>using <i>musa </i>ferments

Publication Date: 2022.10.25 TCI CO LTD(CN)

AI summary

Provided is a method of promoting the growth of Akkermansia muciniphila, including contacting A. muciniphila with an effective amount of a prebiotic composition including a Musa ferment. Also provided is a prebiotic composition including a Musa ferment. The prebiotic composition promotes the growth of A. muciniphila in the intestine, and reduces the body weight, fat percentage, waist circumference, and hip circumference of obese individuals.