Volatile Organic Compound Antimicrobial Composition for Ringworm Treatment
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Solution Overview
Problem
Current treatments for Trichophyton infections, such as ringworm, are often ineffective and can have adverse side effects, with existing antifungal medications only inhibiting rather than killing the infection and posing risks to kidney and liver health, while over-the-counter remedies lack proven effectiveness.
Innovation Solution
A concentrated antimicrobial solution and cream containing an antimicrobial composition based on volatile by-products of Muscodor crispans, combined with solubilizing agents and essential oils, are developed to inhibit the growth of Trichophyton organisms on both biotic and abiotic surfaces, with the antimicrobial composition comprising specific compounds like acetaldehyde, ethyl acetate, and isobutyric acid, and applied topically or used to disinfect surfaces.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If oral fungistat medications (flucanozole group) are used to treat Trichophyton infections, then the infection growth is inhibited, but the treatment is ineffective at killing the underlying infection and causes adverse side effects on kidneys and liver
Solution Approach 1:
The patent extracts and utilizes specific volatile organic compounds (acetaldehyde, ethyl acetate, isobutyric acid, phenylethyl acetate, and methyl isobutyrate) from natural sources to create an antimicrobial composition that kills Trichophyton organisms directly, replacing the ineffective oral fungistat medications that only inhibit growth while causing organ damage
Solution Approach 2:
The patent changes the chemical parameters by using a specific combination of volatile organic compounds at optimized concentrations (acetaldehyde 0.5-5%, ethyl acetate 5-20%, isobutyric acid 0.5-5%, phenylethyl acetate 0.5-5%, methyl isobutyrate 5-20%) to achieve both killing of the fungus and safety for human tissues, resolving the contradiction between effectiveness and side effects
2Reliability
If conventional antifungal treatments are used, then some infection inhibition is achieved, but the treatments only inhibit rather than kill the underlying infection
Solution Approach 1:
The patent creates a composite antimicrobial composition combining five specific volatile organic compounds (acetaldehyde, ethyl acetate, isobutyric acid, phenylethyl acetate, and methyl isobutyrate) in optimized ratios, where the synergistic interaction of these components achieves complete killing of Trichophyton organisms rather than mere inhibition
3Ease of operation
If over-the-counter and home remedies are used to treat dermatophytosis, then treatment options are available, but effectiveness is questionable
Solution Approach 1:
The patent segments the treatment approach into two distinct formulations: a concentrated antimicrobial solution for abiotic surface disinfection and an antimicrobial cream for biotic surface (skin) treatment, providing accessible and effective treatment options for both prevention and active infection management
4Reliability
If concentrated antimicrobial solution is used to disinfect abiotic surfaces, then ringworm spread is prevented, but proper mixing and application is required
Solution Approach 1:
The patent provides a pre-formulated concentrated antimicrobial solution containing all necessary components (acetaldehyde 0.5-5%, ethyl acetate 5-20%, isobutyric acid 0.5-5%, phenylethyl acetate 0.5-5%, methyl isobutyrate 5-20%, and water) that requires only mixing with water before use, eliminating the need for users to separately measure and combine multiple chemicals while maintaining disinfection effectiveness
Data Source
AI summary
Embodiments of the disclosure relate to treatments for ringworm on biotic and abiotic surfaces. According to one aspect, a concentrated antimicrobial solution is provided. The concentrated solution includes an antimicrobial composition, a solubilizing agent, and an essential oil. The concentrated antimicrobial solution can be mixed with water, and the resulting solution can be used to disinfect abiotic surfaces from ringworm. According to another aspect, an antimicrobial cream is provided. The antimicrobial cream includes a carrier including a humectant and an antimicrobial composition dispersed in the carrier at 1% w/v or greater.