Muscular Tissue Grasper for Controlled GI Defect Closure
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Solution Overview
Problem
Existing endoscopic closure devices are inadequate for repairing defects at the muscular layer of gastrointestinal tissue, as Through-The-Scope clips are limited to superficial closure and Over-The-Scope-Clips are difficult to use and lack controlled actuation.
Innovation Solution
A tissue repair device with a tissue-penetrating arm and a tissue-grasping arm, capable of penetrating and grasping muscular tissue, allowing for controlled closure of defects at the muscular layer.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If Through-The-Scope clips are used for tissue closure, then ease of operation is improved, but closure depth is limited to superficial layers only
Solution Approach 1:
The device employs a nested configuration where the grasper arms are contained within a delivery catheter during insertion, then deployed outward to grasp tissue at deep muscular layers. This nesting allows the device to achieve deep closure while maintaining the ease of operation through the catheter delivery mechanism.
Solution Approach 2:
The device transitions from superficial plane closure to deep three-dimensional closure by extending grasper arms through the catheter lumen to reach the muscular layer. This dimensional extension enables closure at multiple depths simultaneously, resolving the contradiction between ease of operation and closure depth.
2Length of stationary object
If Over-The-Scope-Clips are used for deep tissue closure, then closure depth is improved, but ease of operation deteriorates due to difficulty in use and lack of controlled actuation
Solution Approach 1:
The device replaces the complex mechanical Over-The-Scope-Clip system with a controlled actuation mechanism driven by a motor or actuator through the catheter. This substitution provides deep closure capability while significantly improving ease of operation through electronic or mechanical actuation control.
Solution Approach 2:
The device introduces an intermediary actuation mechanism between the operator and the grasper arms, allowing controlled deployment and closure through a motor or actuator system. This intermediary provides precise control for deep tissue closure while maintaining ease of operation through automated or semi-automated actuation.
3Device complexity
If existing closure devices are used, then device complexity is reduced, but reliability of muscular layer repair deteriorates
Solution Approach 1:
The device segments the closure function into distinct components: a delivery catheter for insertion, grasper arms for tissue engagement, and an actuation mechanism for closure. This segmentation allows each component to be optimized for its specific function, improving overall reliability while keeping individual components relatively simple.
Solution Approach 2:
The device achieves multi-functionality by integrating delivery, grasping, and closure actuation functions into a single system. This universal design improves reliability for muscular layer repair while avoiding the need for multiple separate devices, thus not significantly increasing overall device complexity.
Data Source
AI summary
A tissue repair device, system, and method for grasping tissue, such as to repair the tissue (e.g., a defect in tissue), by anchoring a tissue-penetrating arm along a first location along the tissue, moving the anchored tissue-penetrating arm to a second location along the tissue, and grasping tissue at the second location with a tissue-grasping arm. The tissue-penetrating arm remains in a substantially axial straight configuration to facilitate tissue penetration. The tissue-grasping arm is movable towards and away from the tissue-penetrating arm to grasp tissue and hold the grasped tissue between the tissue-grasping arm and the tissue-penetrating arm. The tissue repair device may be left in place holding the tissue in the grasped configuration.