Muse Cell Preparation for Cerebral Infarction Tissue Regeneration
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Solution Overview
Problem
Current treatments for cerebral infarction, such as thrombolytic therapy, are not effective in restoring brain function and preventing sequelae like movement and sensory impairments, and stem cell therapy has not demonstrated adequate therapeutic effects for this condition.
Innovation Solution
A cell preparation containing pluripotent SSEA-3-positive Muse cells, which are isolated from mesenchymal tissue and capable of differentiating into brain cells, is administered to the cerebral parenchyma to reduce infarct size and improve brain function by regenerating damaged tissue.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If thrombolytic therapy is used to restore blood flow to penumbra region, then cerebral blood flow is improved, but therapeutic effect is insufficient to prevent nerve cell death and restore brain function
Solution Approach 1:
The patent introduces pluripotent stem cells as an intermediary substance that mediates between the ischemic damage and tissue regeneration. These cells are administered to the penumbra region where they differentiate into nerve cells, acting as a biological mediator that bridges the gap between restored blood flow and functional recovery, thereby enhancing the therapeutic effect beyond what thrombolytic therapy alone can achieve
Solution Approach 2:
The patent changes the therapeutic parameter from purely mechanical/chemical (thrombolytic agents dissolving clots) to biological (pluripotent stem cells that can differentiate and regenerate tissue). This parameter change allows the treatment to not only restore blood flow but also actively regenerate damaged nerve cells, improving reliability of therapeutic outcome
2Ease of manufacture
If stem cell therapy is administered to treat cerebral infarction, then tissue regeneration is expected, but adequate therapeutic effects have not been demonstrated
Solution Approach 1:
The patent employs pluripotent stem cells that possess multi-functionality: they can differentiate into multiple cell types including nerve cells, provide trophic support to existing cells, reduce inflammation, and promote angiogenesis. This universality ensures that a single cell therapy intervention can address multiple pathological mechanisms simultaneously, thereby demonstrating adequate therapeutic effects that previous more specialized stem cell therapies failed to achieve
Solution Approach 2:
The patent utilizes pluripotent stem cells that have been prepared and characterized in advance for optimal therapeutic potential. These cells are cultured and differentiated under controlled conditions before administration, ensuring they are in the most effective state for treating cerebral infarction. This preliminary preparation and characterization of cells enhances the reliability of therapeutic outcomes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Muse cell preparation significantly reduces infarct size and improves brain function by differentiating into nerve cells and other brain tissue components, demonstrating therapeutic potential for cerebral infarction and its sequelae.
Implementation Method 1
capable of differentiating into brain cells
Implementation Method 2
differentiating into nerve cells and other brain tissue components
Data Source
AI summary
An object of the present invention is to provide a novel medical application to regenerative medicine that uses pluripotent stem cells (Muse cells). The present invention provides a cell preparation for treating cerebral infarction and sequelae associated therewith that contains SSEA-3-positive pluripotent stem cells isolated from mesenchymal tissue in the body or cultured mesenchymal cells. The cell preparation of the present invention is based on a brain tissue regeneration mechanism by which Muse cells differentiate into nerve cells and the like in damaged brain tissue by administering Muse cells into cerebral parenchyma.