Myocardial Conductivity Lines to Prevent Irregular Wave Propagation

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Solution Overview

Problem

Conventional ablation therapies for cardiac arrhythmias, such as pulmonary vein isolation, are often ineffective and can induce secondary arrhythmias, while techniques to increase myocardial conductivity have not been adequately explored.

Innovation Solution

Injecting conductive materials, such as carbon nanotube or metal nanowire suspensions, or applying conductive patches, to create lines of increased conductivity in the myocardium, either by direct injection or attachment, to synchronize depolarization waves and prevent irregular electromechanical waves.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If ablation therapy is applied to treat arrhythmias, then arrhythmia symptoms are reduced, but tissue conductivity is damaged and secondary arrhythmias may occur

Engineering Contradiction:

Improvearrhythmia treatment effectivenessVSAvoidtissue damage and secondary arrhythmias

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Instead of destroying tissue to block arrhythmias (ablation), this invention applies conductive materials to enhance tissue conductivity and restore normal electrical propagation, thereby preventing arrhythmias through a reverse approach that preserves tissue integrity

Inventive Principle:

Principle #13The other way round (Inversion)

Solution Approach 2:

The invention converts the harmful effect of fibrotic lesions and conductivity impairments into a benefit by applying conductive materials that compensate for these defects, transforming areas of decreased conductivity into regions of restored or enhanced conductivity to prevent rotor formation

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Reliability

If conductive materials are injected to increase myocardial conductivity, then electrical conduction is restored, but the complexity of the treatment procedure increases

Engineering Contradiction:

Improveelectrical conduction restorationVSAvoidtreatment procedure complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The invention uses conductive materials (carbon nanotubes, metal nanowires, conductive polymers) as intermediary substances that are injected into the myocardium to mediate between impaired tissue regions, restoring electrical conduction without requiring complex surgical interventions or device implantations

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the electrical conductivity parameter of the myocardial tissue by introducing conductive materials, thereby restoring normal electrical propagation characteristics without altering the fundamental structure or requiring complex procedural modifications

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances tissue conductivity, reducing the occurrence of arrhythmias by stabilizing wave propagation and restoring the electrical conduction system, offering an alternative to ablation therapies with potentially fewer side effects.

Implementation Method 1

substances with high conductivity, as carbon nanotube suspensions or metal nanowire suspensions, are injected in the myocardium to increase the conductivity of the myocardium

Methodology Applied

Scientific EffectElectrical conduction: Conduction (electrical)

Data Source

PatentUS12544485B2Method to prevent propagation of irregular electromechanical waves in the myocardium by creating lines of increased tissue conductivity

Publication Date: 2026.02.10 UNIVERSITY OF HEIDELBERG

AI summary

The present invention relates to compositions, methods, and devices for preventing irregular electromechanical waves in the myocardium that lead to pathological conditions as arrhythmia. In particular, the invention relates to compositions and methods to increase the conductivity of the myocardium to restore an impairment of the electrical conduction system of the heart. To that end substances with high conductivity, as carbon nanotube suspensions or metal nanowire suspensions, are injected in the myocardium at closely adjacent locations on circular or open lines or are introduced in patches of cardiomyocytes that are subsequently placed on the myocardium.