N-Formylloline Compositions for Stable Pest Control

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Solution Overview

Problem

There is a lack of effective and stable compositions comprising loline alkaloids for use in agricultural, horticultural, medical, and veterinary applications as pesticides.

Innovation Solution

Development of compositions comprising N-formylloline with specific molar ratios of hydroxyl and nitrogen-containing groups and nucleophilicity coefficients, along with solvents, to enhance stability and efficacy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If compositions comprising loline alkaloids are developed for agricultural use, then pesticidal effectiveness is improved, but stability is insufficient

Engineering Contradiction:

Improvepesticidal effectivenessVSAvoidcomposition stability

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies parameter changes by precisely controlling the molar ratio of hydroxyl groups and nitrogen-containing groups to N-formylloline (Formula II) within specific ranges (less than about 20, or greater than about 20 with nucleophilicity coefficients less than about 0.6 eV). This chemical parameter optimization stabilizes the composition while maintaining pesticidal activity against insects and other pests.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite composition system combining N-formylloline (Formula II) with specific solvents and auxiliary substances in controlled ratios. This composite approach enhances both the stability and effectiveness of the loline alkaloid composition for agricultural applications.

Inventive Principle:

Principle #40Composite materials

2Stability of the object's composition

If N-formylloline composition is formulated with specific molar ratios, then stability is improved, but formulation complexity increases

Engineering Contradiction:

ImproveN-formylloline stabilityVSAvoidformulation complexity

Core Design Contradiction:

Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent simplifies formulation complexity by establishing clear numerical criteria for composition stability: (a) molar ratio of total hydroxyl groups and nitrogen-containing groups to N-formylloline less than about 20, or (b) molar ratio greater than about 20 with nucleophilicity coefficients less than about 0.6 eV. These quantifiable parameters guide straightforward formulation development.

Inventive Principle:

Principle #35Parameter changes

3Reliability

If loline alkaloid composition is used as pesticide, then pest control effectiveness is improved, but composition degradation occurs over time

Engineering Contradiction:

Improvepest control effectivenessVSAvoidcomposition shelf life

Core Design Contradiction:

ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent extends shelf life by controlling the chemical environment parameters - specifically limiting the molar ratio of reactive groups (hydroxyl and nitrogen-containing groups) to less than 20 times that of N-formylloline, or maintaining nucleophilicity coefficients below 0.6 eV when ratios exceed 20. This prevents composition degradation while preserving pest control effectiveness.

Inventive Principle:

Principle #35Parameter changes

Data Source

PatentUS12606569B2Alkaloid-containing compositions and uses thereof

Publication Date: 2026.04.21 BIOTELLIGA HLDG

AI summary

The present invention provides compositions comprising loline alkaloids including pesticidal compositions, methods of producing the compositions and uses of the compositions including uses as control agents. Methods for the control of pests, including plant or animal pests, for the enhancement of plant growth or reproduction, and treatment and prevention of insect infection and infestation, for example in plants or animals, are also provided.