N2O/O2 Gas Delivery System with Oxygen Analysis and Thermal Control

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Solution Overview

Problem

Existing systems for delivering a 50%/50% nitrous oxide (N2O)/oxygen (O2) gas mixture, commonly used for chronic pain treatment, face challenges in preventing misuse and ensuring pharmaceutical compliance, especially in settings with minimal medical supervision, and are hindered by the risk of mixture demixing at low temperatures, leading to unsafe administration.

Innovation Solution

A system comprising a gas container with an N2O/O2 mixture connected to a gas distribution device that includes oxygen content analysis, control mechanisms to ensure compliance with desired oxygen levels, and a user interface for selecting delivery modes, preventing gas distribution if oxygen levels are not met, and featuring a locking system to prevent unauthorized use.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If MEOPA is stored in a cylinder at low temperature, then storage is possible, but the gas mixture separates into liquid and gas phases causing unsafe composition

Engineering Contradiction:
Improvestorage temperatureVSAvoidgas mixture homogeneity
Core Design Contradiction:
TemperatureVSStability of the object's composition

Solution Approach 1:

The patent changes the physical state parameters of the gas mixture by maintaining it in a supercritical state through controlled temperature and pressure parameters. The cylinder is equipped with heating elements and insulation to maintain temperature above the critical point, preventing phase separation while enabling compact storage. This resolves the contradiction by transforming the storage conditions from subcritical (where phase separation occurs) to supercritical (where homogeneity is maintained).

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The system incorporates preventive measures before temperature-induced separation can occur. Heating elements and thermal insulation are pre-installed in the cylinder to maintain temperature above the critical point before any storage occurs. Temperature sensors and control systems are pre-configured to detect and correct temperature drops before phase separation can happen, cushioning against the harmful effect in advance.

Inventive Principle:
Principle #11Beforehand cushioning (Prior cushioning)

2Ease of operation

If chronic pain patients are treated outside hospital with minimal supervision, then accessibility and convenience improve, but risk of misuse and dosage errors increases

Engineering Contradiction:
Improvetreatment accessibilityVSAvoiddosage safety
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The system incorporates automated safety mechanisms that operate without continuous medical supervision. The control system automatically monitors gas composition, temperature, and pressure, and prevents operation when parameters are outside safe ranges. The device self-regulates dosage based on pre-programmed protocols, eliminating the need for constant human oversight while maintaining safety. This enables reliable home use by making the system self-monitoring and self-correcting.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The system incorporates multiple sensors that continuously monitor gas composition, temperature, and pressure, providing real-time feedback to the control system. When deviations from safe parameters are detected, the system automatically adjusts or shuts down operation. This closed-loop feedback mechanism ensures dosage safety even when used by patients with minimal medical supervision, as the system self-corrects before unsafe conditions can develop.

Inventive Principle:
Principle #23Feedback

3Reliability

If strict storage procedures are implemented to prevent demixing, then gas composition safety is maintained, but operational complexity and storage requirements increase

Engineering Contradiction:
Improvegas composition safetyVSAvoidstorage procedure complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces complex mechanical storage procedures (manual positioning, temperature monitoring, and handling protocols) with an automated thermodynamic system. The cylinder incorporates heating elements, thermal insulation, and temperature sensors that automatically maintain supercritical conditions without requiring manual intervention. This substitution of automated thermal control for manual procedural complexity resolves the contradiction by maintaining gas composition safety through automated physical control rather than complex operational procedures.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures safe and compliant delivery of the N2O/O2 mixture, preventing misuse and overdose, while managing the risks associated with mixture demixing, thereby ensuring patient safety and facilitating administration in various medical supervision environments.

Implementation Method 1

analytical means for measuring the oxygen content of the N2O/O2 gas mixture

Methodology Applied
Scientific EffectGas analysis:

Implementation Method 2

At this temperature, the gaseous nitrous oxide will condense into a liquid phase

Methodology Applied
Scientific EffectCondensation: Condensation

Implementation Method 3

the gas mixture will no longer be homogeneous

Methodology Applied
Scientific EffectPhase change: Phase Change

Data Source

PatentEP3701989B1System for administering a gaseous mixture for the treatment of chronic pain
Publication Date: 2023.07.12 LAIR LIQUIDE SA POUR LETUDE & LEXPLOITATION DES PROCEDES GEORGES CLAUDE
  • EP3701989B1 patent drawingFigure 1

AI summary

The invention relates to a system for delivering a gaseous mixture of nitrous oxide and oxygen, comprising a gas container (1) containing said N2O/O2 mixture fluidly connected to a gas distribution device (2), which includes an internal gas passage (5) branching into a first (7) and a second branch (8), each equipped with a gas outlet (10, 11). Analytical means (3) are used to measure an oxygen content and provide the measured content to control means (4) configured to compare the measured oxygen content provided by the analytical means (3) to a desired oxygen content. Gas supply control means (9) are provided to prevent or interrupt the gas distribution by the gas distribution device (2) when the measured oxygen content differs from the desired content.A human-machine interface (12) allows selection of a delivery mode for the gas mixture in flow rate or pressure, and switching means (13) are used to supply gas to the first branch (7) or, alternatively, to the second branch (8) of the internal gas passage (5) depending on the delivery mode selected.